3-苄氧基-4-甲氧基苯甲醛合成路线 （共 78 条）
反应条件
hydrogen; palladium on activated charcoal
参考文献
Barton,D.H.R. et al.
Journal of the Chemical Society, 1963 , p. 4545 - 4558
反应条件
1: (i) NH2OH*HCl, Py, (ii) DCC, CuSO4*5H2O, Et3N 2: H2 / Pd-C View Scheme
参考文献
Vowinkel,E.; Bartel,J.
Chemische Berichte, 1974 , vol. 107, p. 1221 - 1227
反应条件
ammonium acetate; acetic acid 4 h; Heating;
参考文献
Bermejo, Almudena; Andreu, Inmaculada; Suvire, Fernando; Leonce, Stephane; Caignard, Daniel H.; Renard, Pierre; Pierre, Alain; Enriz, Ricardo D.; Cortes, Diego; Cabedo, Nuria
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5058 - 5068
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C 1.2: 54 percent / tetrahydrofuran; hexane / 20 °C 2.1: 16 percent / AlCl3; N,N-dimethylaniline / CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 16 p. 3546 - 3554
反应条件
1: NH4OAc; AcOH 2: LAH / tetrahydrofuran 3: H2 / Pd/C View Scheme
参考文献
Ma, Dawei; Wu, Wengen; Yang, Guoxin; Li, Jingya; Li, Jia; Ye, Qizhuang
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 47 - 50
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C 2: water; potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere 3: 4-(N,N-dimethlyamino)pyridine / 12 h / 70 °C / Inert atmosphere 4: 1 h / 50 °C / Inert atmosphere; Neat (no solvent); Sealed tube 5: zinc(II) chloride / 1,4-dioxane / 192 h / 100 °C / Inert atmosphere View Scheme
参考文献
Jerezano, Alberto; Jimenez, Fabiola; Del Carmen Cruz, Maria; Montiel, Luisa E.; Delgado, Francisco; Tamariz, Joaquin
Helvetica Chimica Acta, 2011 , vol. 94, # 2 p. 185 - 198
反应条件
1: 88 percent / NH4OAc; AcOH / 4 h / Heating 2: 63 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 2 h / Heating 3: 5percent aq. NaOH / CH2Cl2 / 2 h / 20 °C 4: conc. HCl / ethanol / 4 h / Heating View Scheme
参考文献
Bermejo, Almudena; Andreu, Inmaculada; Suvire, Fernando; Leonce, Stephane; Caignard, Daniel H.; Renard, Pierre; Pierre, Alain; Enriz, Ricardo D.; Cortes, Diego; Cabedo, Nuria
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5058 - 5068
反应条件
1: 87 percent / NaOMe / tetrahydrofuran; methanol / 25 h / -18 - 4 °C 2: 72 percent / xylene / 14 h / 140 °C 3: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 4 h / 25 °C 4: 38 percent / H2 / Pd/C / tetrahydrofuran; methanol / 3 h / 25 °C / 760 Torr View Scheme
参考文献
Tichenor, Mark S.; Kastrinsky, David B.; Boger, Dale L.
Journal of the American Chemical Society, 2004 , vol. 126, # 27 p. 8396 - 8398
反应条件
1: 73 percent / diethyl ether / 2 h / Ambient temperature 2: 88 percent / potassium chromate / acetone / 0.75 h / 10 °C View Scheme
参考文献
Janin; Bisagni
Tetrahedron, 1993 , vol. 49, # 45 p. 10305 - 10316
反应条件
1: 81 percent / NH4OAc / acetic acid / 2 h / Heating 2: 62 percent / Na / CH2Cl2 / 0.08 h / Ambient temperature View Scheme
参考文献
Battersby,A.R. et al.
Tetrahedron, 1961 , vol. 14, p. 46 - 53
