3-苄氧基-4-甲氧基苯甲醛合成路线 （共 78 条）
反应条件
1: 90 percent / NaBH4 / methanol / 1 h / 20 °C 2: 85 percent / SOCl2 / dioxane / 1 h / 20 °C View Scheme
参考文献
Suau, Rafael; Valpuesta, Maria; Torres, Gregorio
Tetrahedron Letters, 1995 , vol. 36, # 8 p. 1315 - 1318
反应条件
potassium tert-butylate in tetrahydrofuran; methanol; water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=-78°C; 1.75 h; 2: With methanol in tetrahydrofuran 0.5 h; Heating / reflux;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 89; 90 ;
反应条件
bromine in tetrachloromethane 2 h; Ambient temperature; Yield given;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 2 p. 95 - 97
反应条件
1: 79 percent / Br2 / dimethylformamide 2: 66 percent / TMSCl; NaI / CH2Cl2 View Scheme
参考文献
Ohmori, Osamu; Takayama, Hiromitsu; Kitajima, Mariko; Aimi, Norio
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 10 p. 1512 - 1513
反应条件
triphenylphosphine in dichloromethane
参考文献
Zein, Ahmed L.; Dakhil, Otman O.; Dawe, Louise N.; Georghiou, Paris E.
Tetrahedron Letters, 2010 , vol. 51, # 1 p. 177 - 180
Title/Abstract Full Text View citing articles Show Details
Zein, Ahmed L.; Dawe, Louise N.; Georghiou, Paris E.
Journal of Natural Products, 2010 , vol. 73, # 8 p. 1427 - 1430
反应条件
1: NaH / tetrahydrofuran / 3 h
2: 0.067 g / H2 / Pd/C / ethyl acetate / 3 h
View Scheme
参考文献
Hernandez-Romero, Yanet; Rojas, Juana-Isela; Castillo, Rafael; Rojas, Alejandra; Mata, Rachel
Journal of Natural Products, 2004 , vol. 67, # 2 p. 160 - 167
反应条件
1: 79 percent / bromine, sodium acetate / acetic acid / Ambient temperature; 1.) 22 h, 2.) 24 h, 3.) 20 h
2: 71 percent / NaOMe / tetrahydrofuran; methanol / 1.) -5 deg C, 5 h, 2.) 4 deg C, 48 h
3: xylene / 1 h / Heating
4: LiAlH4 / diethyl ether / 1.) 4 h, reflux, 2.) overnight, RT
5: 84 percent / MnO2 / CH2Cl2 / 0.75 h / Heating
6: 70 percent / Rh(PPh3P)2CO(Cl), 1,3-bis(diphenylphosphino)propane / 1,3,5-trimethyl-benzene / 1.3 h / Heating
7: 1.) 1.8 M t-butyl-lithium / 1.) THF, hexane, -78 deg C, 1 h; 2.) THF, hexane, -78 deg C, 1 h
View Scheme
参考文献
Bolton, Richard E.; Moody, Christopher, J.; Rees, Charles W.; Tojo, Gabriel
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 931 - 936
反应条件
1: fumic HNO3 / 1,2-dichloro-ethane / 3 h / -15 °C
2: CF3COOH / 60 °C
3: 98 percent / 4-(dimethylamino)pyridine / 1 h
4: KF, 18-crown-8 / propan-2-ol / 5 h
5: acetic anhydride, sodium acetate / overnight
6: 94 percent / K2CO3 / ethanol / Ambient temperature
7: 43 percent / H2 / 10percent Pd/C / methanol / 2 h / 775.7 Torr
View Scheme
参考文献
Rogers, C. Bradford; Blum, Charles A.; Murphy, Bryan P.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 941 - 943
反应条件
1: 1.) NaOEt / 1.) EtOH, RT, 20 min, 2.) EtOH, reflux, 6 h
2: 98 percent / KOH / ethanol / 4 h / Heating
3: 91 percent / aq. CF3COOH / CH2Cl2 / 12 h / Heating
4: 99 percent / pyridine / CH2Cl2 / 1.5 h / Ambient temperature
5: 33 percent / H2 / 5percent Pd/C / ethyl acetate / 6 h / Ambient temperature
6: 99 percent / NaOEt / ethanol / 0.05 h / Heating
View Scheme
参考文献
Zehnter; Gerlach
Tetrahedron Asymmetry, 1995 , vol. 6, # 11 p. 2779 - 2786
