3-苄氧基-4-甲氧基苯甲醛合成路线 （共 78 条）
反应条件
1: 88 percent / NH4OAc; AcOH / 4 h / Heating
2: 63 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 2 h / Heating
3: 5percent aq. NaOH / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Bermejo, Almudena; Andreu, Inmaculada; Suvire, Fernando; Leonce, Stephane; Caignard, Daniel H.; Renard, Pierre; Pierre, Alain; Enriz, Ricardo D.; Cortes, Diego; Cabedo, Nuria
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5058 - 5068
反应条件
in ethanol; ethyl acetate; isopropyl alcohol
参考文献
SYMRISE AG
Patent: US2011/189108 A1, 2011 ;
反应条件
1: 98.6 percent / benzene / 2 h / Heating
2: 94.4 percent / H2 / platinum oxide / ethanol / 2 h / Ambient temperature
3: 31.1 percent / potassium carbonate / 0.5 h / 40 °C
4: 1.) conc. HCl, 2.) aq. NH4OH, sodium borohydride / 1) ethanol, reflux, 2 h; 2) ethanol, room temperature, 2 h
View Scheme
参考文献
Masood, M.; Tiwari, K. P.
Acta Chimica Hungarica, 1983 , vol. 113, # 2 p. 177 - 182
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; sodium hydride; para-thiocresol in 1,1-dimethylpropan-1-ol; mineral oil
T=20°C; 16 h; Inert atmosphereReflux;
参考文献
Romanov-Michailidis, Fedor; Viton, Florian; Fumeaux, Rene; Leveques, Antoine; Actis-Goretta, Lucas; Rein, Maarit; Williamson, Gary; Barron, Denis
Organic Letters, 2012 , vol. 14, # 15 p. 3902 - 3905
反应条件
1: NaBH4 / tetrahydrofuran; ethanol / 0 - 20 °C
2: PBr3 / CH2Cl2 / 0 °C
View Scheme
参考文献
Annapurna, G. S.; Deshpande, V. H.
Synthetic Communications, 1983 , vol. 13, # 13 p. 1075 - 1082
反应条件
aniline hydrochloric acid
参考文献
Sun, Chang-Ming; Lin, Lee-Gin; Yu, Hsi-Jung; Cheng, Chih-Yu; Tsai, Ya-Chuan; Chu, Chi-Wei; Din, Yi-Hui; Chau, Yat-Pang; Don, Ming-Jaw
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1078 - 1081
反应条件
nitric acid
T=0 - 20°C; 1.5 h;
参考文献
Patteux, Claudine; Foucout, Lenaig; Bohn, Pierre; Dupas, Georges; Leprince, Jerome; Tonon, Marie-Christine; Dehouck, Benedicte; Marsais, Francis; Papamicael, Cyril; Levacher, Vincent
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 5 p. 817 - 825
反应条件
1: NaBH4, 0.5N aq. NaOH / tetrahydrofuran / 2.5 h / Ambient temperature
2: SOCl2 / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature
3: 18-crown-6 / acetonitrile / 7 h / Heating
4: aq. KOH / ethanol / 4 h / Heating
5: thionyl chloride / toluene / 2 h / 80 °C
View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
1.1: 100 percent / sodium acetate / 0.08 h / microwave irradiation
2.1: NaOH / 90 °C
2.2: 81 percent / H2O2
3.1: LAH
View Scheme
参考文献
Yasui, Yoshizumi; Koga, Yukiko; Suzuki, Keisuke; Matsumoto, Takashi
Synlett, 2004 , # 4 p. 615 - 618
反应条件
sodium tetrahydroborate
参考文献
Hara; Shirai; Hoshino; Umezawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3107 - 3112
