1,3-二氢-1-[1'-[(2-甲基苯基)甲基][1,4'-联哌啶]-4-基]-2H-苯并咪唑-2-酮合成路线 （共 5 条）
反应条件
1: With acetic acid in dichloromethane
T=0°C; 1 h;
2: With sodium tris(acetoxy)borohydride in dichloromethane
T=0 - 20°C; 16 h;
参考文献
Rasheed, Mohammed Abdul; Shaik, Nagul Meera; Nirogi, Ramakrishna
Synthetic Communications, 2013 , vol. 43, # 13 p. 1796 - 1801
反应条件
MP-triacetoxyborohydride in dichloromethane
参考文献
Bridges, Thomas M.; Brady, Ashley E.; Phillip Kennedy; Nathan Daniels; Miller, Nicole R.; Kim, Kwango; Breininger, Micah L.; Gentry, Patrick R.; Brogan, John T.; Jones, Carrie K.; Jeffrey Conn; Lindsley, Craig W.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5439 - 5442
反应条件
1.1: acetic acid / dichloromethane / 0.25 h / 0 °C
1.2: 16 h / 0 - 20 °C
2.1: dichloromethane / 0.5 h / 0 - 20 °C
3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
4.1: acetic acid / dichloromethane / 1 h / 0 °C
4.2: 16 h / 0 - 20 °C
View Scheme
参考文献
Rasheed, Mohammed Abdul; Shaik, Nagul Meera; Nirogi, Ramakrishna
Synthetic Communications, 2013 , vol. 43, # 13 p. 1796 - 1801
反应条件
1.1: acetic acid / dichloromethane / 0.25 h / 0 °C
1.2: 16 h / 0 - 20 °C
2.1: dichloromethane / 0.5 h / 0 - 20 °C
3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
4.1: acetic acid / dichloromethane / 1 h / 0 °C
4.2: 16 h / 0 - 20 °C
View Scheme
参考文献
Rasheed, Mohammed Abdul; Shaik, Nagul Meera; Nirogi, Ramakrishna
Synthetic Communications, 2013 , vol. 43, # 13 p. 1796 - 1801
反应条件
1.1: dichloromethane / 0.5 h / 0 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
3.1: acetic acid / dichloromethane / 1 h / 0 °C
3.2: 16 h / 0 - 20 °C
View Scheme
参考文献
Rasheed, Mohammed Abdul; Shaik, Nagul Meera; Nirogi, Ramakrishna
Synthetic Communications, 2013 , vol. 43, # 13 p. 1796 - 1801
