4-羟基-7-甲氧基喹啉-3-甲酸乙酯合成路线 （共 10 条）
反应条件
in diphenylether; ethanol T=132 - 270°C; 0.916667 h;
参考文献
PFIZER INC.
Patent: WO2005/21554 A1, 2005 ;
Location in patent: Page/Page column 94-95 ;
反应条件
in diphenylether 1 h; Reflux;
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
1: toluene / Heating 2: diphenyl ether / 250 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 12 p. 2980 - 2985
反应条件
1: toluene / Heating 2: diphenyl ether / 250 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 12 p. 2980 - 2985
反应条件
sodium hydroxide in water 1 h; Reflux;
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
1: 2 N NaOH / Heating 2: diphenyl ether / 1 h / Heating 3: POCl3 / 1.17 h / 100 - 110 °C View Scheme
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
trichlorophosphate 5 h; Heating;
参考文献
Karolak-Wojciechowska, Janina; Lange, Jerzy; Ksiazek, Waldemar; Gniewosz, Malgorzata; Rump, Slawomir
Farmaco, 1998 , vol. 53, # 8-9 p. 579 - 585
反应条件
1: sodium hydroxide / water / 1 h / |Reflux 2: diphenylether / 1 h / |Reflux 3: trichlorophosphate / 0.33 h / 140 °C 4: ammonium hydroxide; zinc(II) chloride / 1.5 h / 160 - 180 °C / 15376.5 Torr / |Microwave irradiation View Scheme
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
1: With potassium hydroxide in water; ethylene glycol T=200°C; P=11377.6 - 12411.9 Torr; 0.5 h; 2: With hydrogenchloride in water; ethylene glycol pH=~ 6; Product distribution / selectivity;
参考文献
PFIZER INC.
Patent: WO2005/21553 A1, 2005 ;
Location in patent: Page/Page column 77 ;
WO 2005/021553 A1
反应条件
1: 2 N NaOH / Heating
2: diphenyl ether / 1 h / Heating
3: POCl3 / 1.17 h / 100 - 110 °C
4: a) 80-100 deg C, 1 h, b) 135-150 deg C, 8 h
View Scheme
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
