1-(环丙基甲基)哌啶-4-醇合成路线 （共 4 条）
反应条件
1: With sodium tetrahydroborate in ethanol
T=0 - 20°C; 16 h;
2: With sodium hydroxide; water in ethanol; dichloromethane
T=20°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/123716 A1, 2005 ;
Location in patent: Page/Page column 95 ;
WO 2005/123716 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; Reflux;
2: With water; sodium hydroxide in tetrahydrofuran
T=0°C; 0.25 h;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/121812 A1, 2009 ;
Location in patent: Page/Page column 117-118 ;
WO 2009/121812 A1
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/94380 A1, 2004 ;
Location in patent: Page 35 ;
WO 2004/094380 A1
反应条件
sodium hydroxide; potassium carbonate in tetrahydrofuran; water
参考文献
Merck and Co., Inc.
Patent: US4031222 A1, 1977 ;
