(R)-(+)-3-甲基戊二酸甲酯合成路线 （共 24 条）
反应条件
N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide in tert-butyl methyl ether T=-20°C; 4 h; optical yield given as percent ee;
参考文献
Park, Sang Eun; Nam, Eun Hye; Jang, Hyeong Bin; Oh, Joong Suk; Some, Surajit; Lee, Yong Seop; Song, Choong Eui
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 13 p. 2211 - 2217
反应条件
pig liver esterase; phosphate buffer) T=23°C;
参考文献
Francis, Christopher J.; Jones, J. Bryan
Journal of the Chemical Society, Chemical Communications, 1984 , # 9 p. 579 - 580
反应条件
Amano P lipase in di-isopropyl ether T=25°C; 6 h; variation of solvent and reaction time; Product distribution;
参考文献
Tetrahedron Letters, , vol. 29, # 14 p. 1717 - 1720
反应条件
pig liver esterase in water T=20°C; pH 7 with KH2PO4-KCl; also with isozyme fractions of esterase enzyme; Yield given;
参考文献
Journal of the American Chemical Society, , vol. 110, # 13 p. 4409 - 4411
反应条件
1: BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 deg C, 2 h 2: 35 percent / AlCl3 / various solvent(s); CH2Cl2; nitromethane / 2 h / Ambient temperature 3: 81 percent / NaOMe / 0.33 h / 7 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 25 p. 7849 - 7854
反应条件
Amano P in toluene T=25°C; 24 h;
参考文献
Yamamoto, Yukio; Yamamoto, Kazuyoshi; Nishioka, Takaaki; Oda, Jun'ichi
Agricultural and Biological Chemistry, 1988 , vol. 52, # 12 p. 3087 - 3092
反应条件
pyridine; oxygen; ozone in methanol T=0°C;
参考文献
Ishmuratov; Bannova; Latypova; Tukhvatshin; Kukovinets; Muslukhov; Tolstikov
Russian Journal of Organic Chemistry, 2013 , vol. 49, # 1 p. 42 - 45
Zh. Org. Khim., 2013 , vol. 49, # 1 p. 52 - 55,4
反应条件
pig liver esterase, 36290 U; sodium hydroxide in methanol; water T=-10°C; pH=7; 63 h; aq. phosphate bufferInert atmosphereEnzymatic reaction; optical yield given as percent ee;
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 48 p. 11373 - 11377
反应条件
sodium methylate T=7°C; 0.333333 h;
参考文献
Konoike; Araki
Journal of Organic Chemistry, 1994 , vol. 59, # 25 p. 7849 - 7854
反应条件
oxygen; ozone; triethylamine in methanol; dichloromethane T=0°C;
参考文献
Russian Journal of Organic Chemistry, , vol. 49, # 1 p. 42 - 45
Zh. Org. Khim., , vol. 49, # 1 p. 52 - 55,4
