2,3,6-三氟-4-吡啶胺(9ci)合成路线 (共 8 条)
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol
P=2585.74 Torr; 18 h;
参考文献
Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin
Patent: US2004/116362 A1, 2004 ;
Location in patent: Page/Page column 11; Figure 1 ;
反应条件
1: 99 percent / aq. NH4OH / 5 h / 20 °C
2: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
ammonium hydroxide; zinc
24 h;
参考文献
Selivanova, Galina A.; Gurskaya, Larisa Yu.; Pokrovskii, Leonid M.; Kollegov, Vitaliy F.; Shteingarts, Vitaliy D.
Journal of Fluorine Chemistry, 2004 , vol. 125, # 12 p. 1829 - 1834
反应条件
1: 85 percent / aq. HClO4 / benzene / 0.08 h / Heating
2: Zn; aq. NH3 / 12 h / 20 °C
View Scheme
参考文献
Laev; Evtefeev; Shteingarts
Journal of Fluorine Chemistry, 2001 , vol. 110, # 1 p. 43 - 46
反应条件
ammonia in 1,4-dioxane; water
T=25°C; Rate constant;
参考文献
Chambers, R. D.; Martin, P. A.; Waterhouse, J. S.; Williams, D. L. H.; Anderson, B.
Journal of Fluorine Chemistry, 1982 , vol. 20, p. 507 - 514
反应条件
1: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 40 percent / conc. H2SO4 / 18 h / 20 °C
3: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 40 percent / conc. H2SO4 / 18 h / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 40 percent / conc. H2SO4 / 18 h / 20 °C
3: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
4: 47 percent / 1 h / 100 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000