4-氨基-2,6-二氟吡啶合成路线 （共 10 条）
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol P=2585.74 Torr; 18 h;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1975 - 2000
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol P=2689.2 Torr; 72 h;
参考文献
McNamara; Cook
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 340 - 347
反应条件
1: With potassium fluoride; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane in dimethyl sulfoxide T=160°C; 72 h; 2: With hydrogenchloride in methanol 1 h;
参考文献
BRACCO IMAGING S.P.A.; SWENSON, Rolf, E.; RAJU, Natarajan; ESTRELLA-JIMENEZ, Maria, E.; RAMALINGAM, Kondareddiar
Patent: WO2011/159864 A1, 2011 ;
Location in patent: Page/Page column 41-42 ;
反应条件
1: 98 percent / aq. NH4OH / 20 °C 2: 33 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1975 - 2000
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h 2.1: potassium fluoride; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane / dimethyl sulfoxide / 72 h / 160 °C 2.2: 1 h View Scheme
反应条件
zinc 8 h; Product distribution; Further Variations:Reagentstime;
参考文献
Journal of Fluorine Chemistry, , vol. 125, # 12 p. 1829 - 1834
反应条件
sodium hydroxide 24 h; Heating;
参考文献
McNamara; Cook
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 340 - 347
反应条件
1: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 89 percent / conc. H2SO4 / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 89 percent / conc. H2SO4 / 20 °C
3: 92 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 89 percent / conc. H2SO4 / 20 °C
3: 92 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
