sodium hydroxide; tris(dibenzylideneacetone)dipalladium (0); P(i-BuNCH2CH2)3N in toluene T=100°C; Buchwald-Hartwig amination; 40 h;

sodium t-butanolate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; palladium diacetate in toluene; tert-butyl alcohol T=120°C; Buchwald-Hartwig amination; 10 h;

copper diacetate; 4 A molecular sieve; oxygen in dichloromethane T=40°C; 24 h;

hydrogenchloride T=100°C;