4-氨基-3-氯-5-(三氟甲基)苯甲酰氯合成路线 （共 6 条）
反应条件
thionyl chloride 2 h; Heating / reflux;
参考文献
Shenyang Pharmaceutical University; Jinzhou Jiutai Pharmaceutical Co., Ltd. China
Patent: EP1439164 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
1: 56 percent / SO2Cl2 / CHCl3 / 8 h / Heating 2: SOCl2 / 2 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 89 percent / toluene / 5 h / Heating 2: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 3: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating 4: 56 percent / SO2Cl2 / CHCl3 / 8 h / Heating 5: SOCl2 / 2 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 2: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating 3: 56 percent / SO2Cl2 / CHCl3 / 8 h / Heating 4: SOCl2 / 2 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating 2: 56 percent / SO2Cl2 / CHCl3 / 8 h / Heating 3: SOCl2 / 2 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: I2, CaCO3 / methanol; H2O / 24 h / 45 °C 2: 89 percent / toluene / 5 h / Heating 3: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 4: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating 5: 56 percent / SO2Cl2 / CHCl3 / 8 h / Heating 6: SOCl2 / 2 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 34, # 11 A p. 1612 - 1624
