2-氨基-5-氯苯甲酸合成路线 （共 147 条）
反应条件
1: HCl 2: pyridine View Scheme
参考文献
Arisawa, Mitsuhiro; Theeraladanon, Chumpol; Nishida, Atsushi; Nakagawa, Masako
Tetrahedron Letters, 2001 , vol. 42, # 45 p. 8029 - 8033
反应条件
1: methanol; 2-amino-5-chloro-benzoic acid With sulfuric acid 2: acetic anhydride in 1,4-dioxane
参考文献
WYETH LLC; TSOU, Hwei-Ru; BIRNBERG, Gary, Harold; MAC EWAN, Gloria, Jean; OTTENG, Mercy, Adufa; NOWAK, Pawel, Wojciech; AYRAL-KALOUSTIAN, Semiramis; MANSOUR, Tarek, Suhayl; ZASK, Arie; YU, Ker
Patent: WO2010/30967 A1, 2010 ;
Location in patent: Page/Page column 60 ;
WO 2010/030967 A1
反应条件
sodium azide; ammonium chloride; trichlorophosphate; N,N-dimethyl-formamide T=0 - 20°C; Curtius rearrangement;
参考文献
Synthetic Communications, , vol. 34, # 4 p. 735 - 742
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
Location in patent: Page/Page column 79 ;
WO 2011/112731 A2
反应条件
1: With acetic acid in water T=30°C; 0.5 h; 2: With sodium hydroxide in water T=30°C; 3: With hydrogenchloride in water pH=7;
参考文献
ARDELYX, INC.; CHARMOT, Dominique; JACOBS, Jeffrey, W.; LEADBETTER, Michael, Robert; NAVRE, Marc; CARRERAS, Chris; BELL, Noah
Patent: WO2010/78449 A2, 2010 ;
Location in patent: Page/Page column 235 ;
WO 2010/078449 A2
反应条件
in water 0.00833333 h; microwave irradiation;
参考文献
Nikpour, Farzad; Paibast, Touraj
Chemistry Letters, 2005 , vol. 34, # 10 p. 1438 - 1439
反应条件
1: 91 percent / NaOH, acetic acid / H2O / 3 h 2: 35 percent / acetic acid / 24 h / 55 °C View Scheme
参考文献
Hoffmann-La Roche Inc.
Patent: US5688803 A1, 1997 ;
反应条件
beim Erhitzen ueber den Schmelzpunkt;
参考文献
Freundler
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1906 , vol. 143, p. 910
Bulletin de la Societe Chimique de France, 1907 , vol. <4> 1, p. 224
反应条件
1: (i) NaNO2, aq. HCl, (ii) KI, aq. H2SO4
2: aq. KOH / Cu
3: LiAlH4 / diethyl ether
4: SOCl2, Py
5: aq. ethanol
6: aq. KOH / ethanol
View Scheme
参考文献
Pelz,K. et al.
Collection of Czechoslovak Chemical Communications, 1968 , vol. 33, # 6 p. 1852 - 1872
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2007/43677 A1, 2007 ;
Location in patent: Page/Page column 538-539 ;
