2-氨基-5-氯苯甲酸合成路线 (共 147 条)
反应条件
triethylamine in tetrahydrofuran; water
T=20°C; 3 h; Inert atmosphere;
参考文献
Kothandaraman, Prasath; Lauw, Sherman Jun Liang; Chan, Philip Wai Hong
Tetrahedron, 2013 , vol. 69, # 35 p. 7471 - 7480
反应条件
1: triethylamine / tetrahydrofuran; water / 3 h / 20 °C / |Inert atmosphere
2: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 0 - 20 °C / |Inert atmosphere
3: tetrahydrofuran / 18 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Kothandaraman, Prasath; Koh, Bing Qin; Limpanuparb, Taweetham; Hirao, Hajime; Chan, Philip Wai Hong
Chemistry - A European Journal, 2013 , vol. 19, # 6 p. 1978 - 1985
反应条件
peroxymonosulfuric acid
参考文献
Freundler; Sevestre
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1908 , vol. 147, p. 983
反应条件
thionyl chloride in benzene
参考文献
Farmitalia Carlo Erba S.p.A.
Patent: US4428952 A1, 1984 ;
反应条件
thionyl chloride in benzene
4 h; Reflux;
参考文献
Jahng, Katherine Chae; Kim, Seung Ill; Kim, Dong Hyeon; Seo, Chang Seob; Son, Jong-Keun; Lee, Seung Ho; Lee, Eung Seok; Jahng, Yurngdong
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 607 - 609
反应条件
phosphorous pentoxide in m-xylene
3 h; Reflux;
参考文献
Ojo, Babatunde; Chowdhury, Bejoy K.
Synthetic Communications, 2012 , vol. 42, # 7 p. 1002 - 1009
反应条件
thionyl chloride in benzene
4 h; Reflux;
参考文献
Jahng, Katherine Chae; Kim, Seung Ill; Kim, Dong Hyeon; Seo, Chang Seob; Son, Jong-Keun; Lee, Seung Ho; Lee, Eung Seok; Jahng, Yurngdong
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 607 - 609
反应条件
pyridine; triphenyl phosphite
T=220°C; 0.166667 h; microwave irradiation;
参考文献
Liu, Ji-Feng; Wilson, Christopher J.; Ye, Ping; Sprague, Kevin; Sargent, Katie; Si, Ying; Beletsky, Galina; Yohannes, Daniel; Ng, Shi-Chung
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 3 p. 686 - 690
反应条件
thionyl chloride
T=100°C;
参考文献
Jaen, Juan C.; Gregor, Vlad E.; Lee, Chet; Davis, Robert; Emmerling, Mark
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 6 p. 737 - 742
参考文献
Jaen, Juan C.; Gregor, Vlad E.; Lee, Chet; Davis, Robert; Emmerling, Mark
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 6 p. 737 - 742