2-氨基-5-氯苯甲酸合成路线 （共 147 条）
反应条件
1: 65 percent / POCl3 / 2 h / Heating
2: 50 percent / NH3; phenol / 4 h / 125 - 130 °C
View Scheme
参考文献
Recanatini, Maurizio; Cavalli, Andrea; Belluti, Federica; Piazzi, Lorna; Rampa, Angela; Bisi, Alessandra; Gobbi, Silvia; Valenti, Piero; Andrisano, Vincenza; Bartolini, Manuela; Cavrini, Vanni
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2007 - 2018
反应条件
1: Heating
2: Zn dust, HCl, AcOH / 50 - 60 °C
View Scheme
参考文献
Jaen, Juan C.; Gregor, Vlad E.; Lee, Chet; Davis, Robert; Emmerling, Mark
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 6 p. 737 - 742
反应条件
1: Heating
2: (i) Mg, Et2O, (ii) /BRN= 140708/, benzene
View Scheme
参考文献
Patterson, Stephen; Alphey, Magnus S.; Jones, Deuan C.; Shanks, Emma J.; Street, Ian P.; Frearson, Julie A.; Wyatt, Paul G.; Gilbert, Ian H.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6514 - 6530
反应条件
1: 3-methoxybromobenzene With n-butyllithium in diethyl ether; hexane
T=-78 - 0°C; 2 h;
2: 2-amino-5-chloro-benzoic acid in tetrahydrofuran; diethyl ether; hexane
T=0°C; 2 h; Further stages;
参考文献
Patterson, Stephen; Alphey, Magnus S.; Jones, Deuan C.; Shanks, Emma J.; Street, Ian P.; Frearson, Julie A.; Wyatt, Paul G.; Gilbert, Ian H.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6514 - 6530
反应条件
1: Heating
2: (i) Mg, Et2O, (ii) /BRN= 140708/, benzene
3: aq. HCl / ethanol
View Scheme
参考文献
Kolbah; Blazevic; Hannoun; et al.
Helvetica Chimica Acta, 1977 , vol. 60, # 1 p. 265 - 283
反应条件
2: 27 percent / M. Lamchen and A. J. Wichen, J. Chem. Soc., 2781 (1959)
3: 86 percent / conc. hydrochloric acid / ethanol / 4 h / Heating
4: 79 percent / aluminium chloride / benzene / Heating
View Scheme
参考文献
Kolbah; Blazevic; Hannoun; et al.
Helvetica Chimica Acta, 1977 , vol. 60, # 1 p. 265 - 283
反应条件
1: 67 percent / dioxane / 12 h / 20 °C
2: 82 percent / conc. H2SO4; KNO3 / 24 h / 20 °C
3: 82 percent / NaOH / H2O / 3 h / Heating
View Scheme
参考文献
Deady, Leslie W.; Kaye, Anthony J.
Australian Journal of Chemistry, 1997 , vol. 50, # 5 p. 473 - 478
反应条件
sulfuric acid
18 h; Heating;
参考文献
Kobayashi, Kazuhiro; Takanohashi, Atsushi; Hashimoto, Kenichi; Morikawa, Osamu; Konishi, Hisatoshi
Tetrahedron, 2006 , vol. 62, # 13 p. 3158 - 3161
参考文献
Raffa, Demetrio; Daidone, Giuseppe; Maggio, Benedetta; Cascioferro, Stella; Plescia, Fabiana; Schillaci, Domenico
Farmaco, 2004 , vol. 59, # 6 p. 451 - 455
反应条件
in ethylene glycol dimethyl ether; ethylene glycol diethyl ether
T=0°C; 2 h; Inert atmosphere;
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 6 p. 1444 - 1447
