2-氨基-5-氯苯甲酸合成路线 （共 147 条）
反应条件
1.1: sodium hydroxide / water / 20 - 45 °C
1.2: 0 - 20 °C
2.1: potassium carbonate; acetic anhydride / 1 h / 90 °C
3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 1 h / Reflux
View Scheme
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
WO 2011/112731 A2
反应条件
in ethanol
3 h; Reflux;
参考文献
Asadi, Mehdi; Masoomi, Shiva; Ebrahimi, Seyed Mostafa; Mahdavi, Mohammad; Saeedi, Mina; Shafiee, Abbas; Foroumadi, Alireza
Monatshefte fur Chemie, 2014 , vol. 145, # 3 p. 497 - 504
反应条件
bromine in acetic acid
T=15°C; 4 h;
参考文献
SCHERING CORPORATION
Patent: EP977739 B1, 2003 ;
Location in patent: Page/Page column 8 ;
反应条件
1: 4-bromo-1,2-dichloro-benzene With n-butyllithium in diethyl ether; hexane
T=-78 - 0°C; 2 h;
2: 2-amino-5-chloro-benzoic acid in tetrahydrofuran; diethyl ether; hexane
T=0°C; 2 h; Further stages;
参考文献
Patterson, Stephen; Alphey, Magnus S.; Jones, Deuan C.; Shanks, Emma J.; Street, Ian P.; Frearson, Julie A.; Wyatt, Paul G.; Gilbert, Ian H.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6514 - 6530
反应条件
in acetic acid
0.5 h; Heating;
参考文献
Deady, Leslie W.; Kaye, Anthony J.
Australian Journal of Chemistry, 1997 , vol. 50, # 5 p. 473 - 478
反应条件
1: aqueous hydrochloric acid; sodium nitrite / Diazotization.Eintragen der erhaltenen Diazoniumsalz-Loesung in eine aus Kupfer(II)-sulfat, Schwefeldioxid und wss. Ammoniak hergestellte Loesung
2: acetic acid anhydride
View Scheme
参考文献
Huntress; Cliff; Atkinson
Journal of the American Chemical Society, 1933 , vol. 55, p. 4262,4270
反应条件
Behandeln des Reaktionsprodukts mit Kondensationsmitteln;
参考文献
Ges. f. chem. Ind. Basel
Patent: DE444984 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 697
