2-氨基-5-氯苯甲酸合成路线 （共 147 条）
反应条件
in 1,4-dioxane T=20°C; 4 h; Heating / reflux;
参考文献
AVANIR PHARMACEUTICALS
Patent: WO2004/74218 A2, 2004 ;
Location in patent: Page 116 ;
反应条件
in 1,4-dioxane; toluene T=20°C; 18 h;
参考文献
Hinschberger, Antoine; Butt, Sabrina; Lelong, Veronique; Boulouard, Michel; Dumuis, Aline; Dauphin, Franccois; Bureau, Ronan; Pfeiffer, Bruno; Renard, Pierre; Rault, Sylvain
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 138 - 147
反应条件
in hydrogenchloride 1.5 h;
参考文献
Baronnet; Callendret; Blanchard; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 241 - 247
反应条件
in toluene 1 h; Reflux;
参考文献
RENASCIENCE CO., LTD.
Patent: US2012/22080 A1, 2012 ;
Location in patent: Page/Page column 67 ;
US 20120022080 A1
参考文献
Akila; Majo; Balasubramanian
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 3 p. 647 - 649
反应条件
Erhitzen der Reaktionsloesung mit ammoniakal. wss. Kupfer(I)-sulfit-Loesung;
参考文献
Huntress; Cliff; Atkinson
Journal of the American Chemical Society, 1933 , vol. 55, p. 4262,4270
反应条件
sodium azide; acetic acid T=0 - 20°C; 19 h;
参考文献
Howard, Nigel; Abell, Chris; Blakemore, Wendy; Chessari, Gianni; Congreve, Miles; Howard, Steven; Jhoti, Harren; Murray, Christopher W.; Seavers, Lisa C. A.; Van Montfort, Rob L. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1346 - 1355
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran; pentane T=-40°C; 0.5 h; 2: 2-amino-5-chloro-benzoic acid in tetrahydrofuran; pentane T=-40 - 0°C; 2 h; 3: With hydrogenchloride; chloro-trimethyl-silane more than 3 stages;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/9967 A2, 2005 ;
Location in patent: Page/Page column 42-43 ;
WO 2005/009967 A2
反应条件
in tetrahydrofuran; diethyl ether; hexane T=0°C; 2 h;
参考文献
Fryer; Zhang; Rios
Synthetic Communications, 1993 , vol. 23, # 7 p. 985 - 992
参考文献
Rogers,G.T.; Ulbricht,T.L.V.
Tetrahedron Letters, 1968 , p. 1029 - 1032
