2-氨基-5-氯苯甲酸合成路线 （共 147 条）
反应条件
1: 2-amino-5-chloro-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; Inert atmosphere; 2: methylamine in tetrahydrofuran 3 h;
参考文献
Morgentin, Remy; Barlaam, Bernard; Foote, Kevin; Hassall, Lorraine; Hawkins, Janet; Jones, Clifford D.; Le Griffon, Antoine; Peru, Aurelien; Ple, Patrick
Synthetic Communications, 2012 , vol. 42, # 1 p. 8 - 24
反应条件
hydrogenchloride; Na2S2; acetic acid; zinc; sodium nitrite Multistep reaction;
参考文献
Sindelar; Jilek; Pomykacek; et al.
Collection of Czechoslovak Chemical Communications, 1978 , vol. 43, # 2 p. 471 - 497
反应条件
sodium nitrite in water; isopropyl alcohol
参考文献
BASF Aktiengesellschaft
Patent: US4172098 A1, 1979 ;
反应条件
1: isoamyl nitrite, iodine / CDCl3; dioxane / 18 h / Heating 2: 65 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene, bis(triphenylphosphine)palladium(II) chloride / N,N-dimethyl-acetamide / 4 h / 115 °C / 4654.3 - 4912.9 Torr View Scheme
参考文献
Perry, Robert J.; Turner, S. Richard
Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6573 - 6579
反应条件
2: 27 percent / M. Lamchen and A. J. Wichen, J. Chem. Soc., 2781 (1959) View Scheme
参考文献
Kolbah; Blazevic; Hannoun; et al.
Helvetica Chimica Acta, 1977 , vol. 60, # 1 p. 265 - 283
反应条件
hydrogen; palladium on activated charcoal in methanol P=735.5 Torr; 80 h; Ambient temperature; Product distribution;
参考文献
Polivka; Jilek; Holubek; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 1 p. 86 - 109
反应条件
in ethanol 5 h; Reflux;
参考文献
Al-Omary, Fatmah A.M.; Hassan, Ghada S.; El-Messery, Shahenda M.; Nagi, Mahmoud N.; Habib, El-Sayed E.; El-Subbagh, Hussein I.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 33 - 45
反应条件
1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 30 °C / |Inert atmosphere 2: manganese(IV) oxide / dichloromethane / 20 °C / |Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 19 p. 5810 - 5831
反应条件
1: HOBt; EDC*HCl; ammonia / dimethylformamide; H2O / 20 °C 2: conc. HCl / 20 °C 3: SOCl2 / dimethylformamide / Heating View Scheme
参考文献
Schonowsky; Sachse
1982 , vol. 37, # 7 p. 907 - 911
反应条件
1: Cyclization; 2: With trichlorophosphate Substitution; 3 h; Heating;
参考文献
Myers, Michael R.; Setzer, Natalie N.; Spada, Alfred P.; Zulli, Allison L.; Hsu, Chin-Yi J.; Zilberstein, Asher; Johnson, Susan E.; Hook, Linda E.; Jacoski, Mary V.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 4 p. 417 - 420
