2-氨基-5-氯苯甲酸合成路线 （共 147 条）
反应条件
1: 37 percent / thionyl chloride / 0.5 h / Heating 2: 68 percent / liq. ammonia / 0.5 h / 0 °C 3: 63 percent / phosphorus pentoxide / 0.5 h View Scheme
参考文献
Mahajan; Mahalakshmi
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 5 p. 1299 - 1300
反应条件
1: With sulfuric acid; iodine T=65 - 140°C; 5.5 - 7.5 h; 2: With ammonia; water T=0°C; pH=6.5;
参考文献
Thombare, Pravin S.; Lohray, Braj Bhushan; Lohray, Vidya Bhushan; Patel, Pankaj Ramanbhai
Patent: US2009/171091 A1, 2009 ;
Location in patent: Page/Page column 6 ;
反应条件
1: tetrahydrofuran / 4 h / 20 °C 2: hydrazine hydrate / ethanol / 2 h / 20 °C View Scheme
参考文献
El-Azzounyl, Aida A.; Maklad, Yousreya A.; Bartsch, Herbert; Zaghary, Wafaa A.; Ibrahim, Waleed M.; Mohamed, Mosaad S.
Scientia Pharmaceutica, 2003 , vol. 71, # 4 p. 331 - 356
反应条件
1: aqueous HCl 2: acetic acid anhydride; potassium acetate / 110 °C View Scheme
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
WO 2011/112731 A2
反应条件
iodine; isopentyl nitrite in 1,4-dioxane; chloroform-d1 18 h; Heating;
参考文献
Perry, Robert J.; Turner, S. Richard
Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6573 - 6579
参考文献
FLYNN, Gary, A.
Patent: WO2013/22766 A1, 2013 ;
Location in patent: Page/Page column 96 ;
WO 2013/022766 A1
反应条件
1: aqueous hydrochloric acid; sodium nitrite / Diazotization.Eintragen der erhaltenen Diazoniumsalz-Loesung in eine aus Kupfer(II)-sulfat, Schwefeldioxid und wss. Ammoniak hergestellte Loesung 2: sulfuric acid / 170 °C 3: concentrated sulfuric acid / 265 - 270 °C View Scheme
参考文献
Huntress; Cliff; Atkinson
Journal of the American Chemical Society, 1933 , vol. 55, p. 4262,4270
参考文献
Merck Patent Gesellschaft Mit
Patent: US5932765 A1, 1999 ;
反应条件
(i) NaNO2, aq. HCl, (ii) KI, aq. H2SO4; Multistep reaction;
参考文献
Zhou, Ping-Xin; Luo, Jian-Yi; Zhao, Lian-Biao; Ye, Yu-Ying; Liang, Yong-Min
Chemical Communications, 2013 , vol. 49, # 31 p. 3254 - 3256
反应条件
1: T=120°C; 3 h; 2: With ammonia in water 4 h; Reflux;
参考文献
Okano, Masahiko; Mito, Jun; Maruyama, Yasufumi; Masuda, Hirofumi; Niwa, Tomoko; Nakagawa, Shin-ichiro; Nakamura, Yoshitaka; Matsuura, Akira
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 119 - 132
