2-氨基-5-氯苯甲酸合成路线 （共 147 条）
反应条件
1: 75.8 percent / 2 h / Heating 2: 54.4 percent / ammonium acetate / 0.5 h / 150 °C View Scheme
参考文献
Jiang, J. B.; Hesson, D. P.; Dusak, B. A.; Dexter, D. L.; Kang, G. J.; Hamel, E.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1721 - 1728
反应条件
in polyethyleneglycol T=140 - 150°C; 4.5 h;
参考文献
Nikpour, Farzad; Mozafari, Roya; Paibast, Touraj
Heterocycles, 2009 , vol. 78, # 6 p. 1569 - 1571
反应条件
1: SOCl2 / 1.5 h / Heating 2: acetone / 0.5 h / 20 °C View Scheme
参考文献
Somers; Ouedraogo; Antoine; De Tullio; Becker; Fontaine; Damas; Dupont; Rigo; Delarge; Lebrun; Pirotte
Journal of Medicinal Chemistry, 2001 , vol. 44, # 16 p. 2575 - 2585
参考文献
Bariana et al.
Journal of the Indian Chemical Society, 1955 , vol. 32, p. 644
反应条件
acetic acid; diethylamine T=150°C; 2 h; Product distribution / selectivity;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP1997812 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
T=210°C; Cycloaddition; 0.25 h;
参考文献
Chao, Qi; Deng, Lynn; Shih, Hsiencheng; Leoni, Lorenzo M.; Genini, Davide; Carson, Dennis A.; Cottam, Howard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3860 - 3873
反应条件
1: HOBt; EDC*HCl; ammonia / dimethylformamide; H2O / 20 °C 2: conc. HCl / 20 °C View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
1.1: triethylamine / toluene / 15 h / 110 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran; dimethyl sulfoxide / 18 h / 20 °C 2.2: 1 h View Scheme
参考文献
Allendoerfer, Nadine; Es-Sayed, Mazen; Nieger, Martin; Braese, Stefan
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 388 - 391
反应条件
1: triethylamine / toluene / 15 h / 110 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C View Scheme
参考文献
Allendoerfer, Nadine; Es-Sayed, Mazen; Nieger, Martin; Braese, Stefan
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 388 - 391
反应条件
(i) aq. NaOH, (ii) /BRN= 385653/, (iii) AcCl; Multistep reaction;
参考文献
Naik; Amin; Patel
Journal of the Indian Chemical Society, 1979 , vol. 56, # 7 p. 708 - 711
