2-氨基-5-氯苯甲酸合成路线 （共 147 条）
反应条件
1: Heating 2: (i) Mg, Et2O, (ii) /BRN= 140708/, benzene 3: aq. HCl / ethanol 4: BBr3 / CH2Cl2 View Scheme
参考文献
Kolbah; Blazevic; Hannoun; et al.
Helvetica Chimica Acta, 1977 , vol. 60, # 1 p. 265 - 283
反应条件
in tetrahydrofuran T=0°C; 6 h;
参考文献
Ren, Lei; Lian, Xiao-Lei; Gong, Liu-Zhu
Chemistry - A European Journal, 2013 , vol. 19, # 10 p. 3315 - 3318
反应条件
1: With sodium carbonate in water T=80°C; 20 h; 2: With hydrogenchloride in diethyl ether; water
参考文献
Cheng, Jingcai
Patent: US2010/137356 A1, 2010 ;
Location in patent: Page/Page column 9 ;
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: Ac2O / 1 h / Heating 3: AcONH4 / 7 h / 220 °C View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1.1: HCl; NaNO2 / 5 °C 1.2: Na2S; S8; NaOH / 5 °C 1.3: Zn; acetic acid / 48 h / Heating 2.1: H2SO4; CH3COSH / 0.25 h / 24 °C View Scheme
参考文献
Sawwan, Nahed; Brzostowska, Edyta M.; Greer, Alexander
Journal of Organic Chemistry, 2005 , vol. 70, # 17 p. 6968 - 6971
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: Ac2O / 1 h / Heating 3: AcONH4 / 7 h / 220 °C 4: POCl3 / 3 h / Heating View Scheme
参考文献
Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
反应条件
1: acetic acid / 0.5 h / Heating 2: 2.0 g / cc. nitric acid / H2SO4 / 1 h / 0 °C 3: 1.40 g / cc. hydrochloric acid / H2O / 1 h / Heating 4: 1.8 g / stannous chloride dihydrate / HCl / 100 °C 5: 1.6 g / H2, KOH / Raney nickel / ethanol 6: 2.) sodium carbonate, deactivated Raney Ni / 1.) acetic acid, water (1:1), 15 min, warming; 2.) water, 70 deg C, 3 h View Scheme
参考文献
Deady, Leslie W.; Kaye, Anthony J.
Australian Journal of Chemistry, 1997 , vol. 50, # 5 p. 473 - 478
反应条件
1: With sulfuric acid; sodium nitrite T=0 - 20°C; 17 h; 2: With potassium iodide in water Further stages.;
参考文献
Poirier, Marc; Chen, Frank; Bernard, Charles; Wong, Yee-Shing; Wu, George G.
Organic Letters, 2001 , vol. 3, # 23 p. 3795 - 3798
反应条件
1: 2-amino-5-chloro-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 2 h; 2: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in tetrahydrofuran T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/32470 A1, 2006 ;
Location in patent: Page/Page column 31-32 ;
反应条件
1.1: tetrahydrofuran / 2 h / 70 °C 2.1: triethylamine / ethanol / 0.17 h 2.2: 2 h / |Reflux View Scheme
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456
