1,2,3,4-四氢喹啉合成路线 （共 372 条）
参考文献
Okimoto, Mitsuhiro; Yoshida, Takashi; Hoshi, Masayuki; Hattori, Kazuyuki; Komata, Masashi; Numata, Kaori; Tomozawa, Kenta
Australian Journal of Chemistry, 2007 , vol. 60, # 4 p. 236 - 242
反应条件
1: in tetrahydrofuran Stolle synthesis; 3 h; Reflux; 2: With AlCl3, aluminium chloride in dichloromethane Stolle synthesis; 3 h; Reflux;
参考文献
Matesic, Lidia; Locke, Julie M.; Vine, Kara L.; Ranson, Marie; Bremner, John B.; Skropeta, Danielle
Tetrahedron, 2012 , vol. 68, # 34 p. 6810 - 6819
反应条件
[3H]-Nicotinic acid; tert.-butylhydroperoxide; copper diacetate in decane; toluene T=110°C; 48 h; Schlenk technique;
参考文献
Liu, Tao; Yang, Haijun; Jiang, Yuyang; Fu, Hua
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 6 p. 1169 - 1176
反应条件
sodium hydroxide; PPA in water
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4317820 A1, 1982 ;
反应条件
1: 63 percent / HNO3; H2SO4 / 0 - 5 °C 2: 81 percent / DDQ / toluene / 1.5 h / 100 °C 3: H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme
参考文献
Westaway, Susan M.; Chung, Ying-Kit; Davis, John B.; Holland, Vicky; Jerman, Jeffrey C.; Medhurst, Stephen J.; Rami, Harshad K.; Stemp, Geoffrey; Stevens, Alexander J.; Thompson, Mervyn; Winborn, Kim Y.; Wright, James
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4533 - 4536
参考文献
Yokoyama; Yamamoto
Bulletin of the Chemical Society of Japan, 1943 , vol. 18, p. 121,123
反应条件
1: 63 percent / HNO3; H2SO4 / 0 - 5 °C 2: 81 percent / DDQ / toluene / 1.5 h / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4533 - 4536
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) THF, hexane, 0 deg C, 2.) 12 h, rt;
参考文献
Ahlbrecht,H.; Duebner,E.O.
Tetrahedron, 1984 , vol. 40, p. 1157
反应条件
sodium hydrogencarbonate in water; ethyl acetate 2.5 h; Ambient temperature;
参考文献
THE WELLCOME FOUNDATION LIMITED
Patent: EP96214 B1, 1991 ;
反应条件
Decaborane in methanol; water T=20°C; 0.5 h;
参考文献
Yeon Joo Jung; Jong Woo Bae; Choon-Ock Maing Yoon; Byung Woo Yoo; Cheol Min Yoon
Synthetic Communications, 2001 , vol. 31, # 22 p. 3417 - 3421
