1,2,3,4-四氢喹啉合成路线 （共 372 条）
反应条件
1: 63 percent / HNO3; H2SO4 / 0 - 5 °C 2: K2CO3 / dimethylformamide / 20 °C View Scheme
参考文献
Westaway, Susan M.; Chung, Ying-Kit; Davis, John B.; Holland, Vicky; Jerman, Jeffrey C.; Medhurst, Stephen J.; Rami, Harshad K.; Stemp, Geoffrey; Stevens, Alexander J.; Thompson, Mervyn; Winborn, Kim Y.; Wright, James
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4533 - 4536
反应条件
1: 1) water / 1) 60-75 deg C, 7 h; 2) 190 deg C, 15 min. in vacuo 2: 1) P2O5 / 1) toluene, boiling for 30 min.; 2) 150-160 deg C, 2.5 h View Scheme
参考文献
Silhankova, Alexandra; Trska, Petr; Vlkova, Daniela; Ferles, Miloslav
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1048 - 1056
参考文献
Shao, Jingyin; Ji, Shaomin; Li, Xiaolian; Zhao, Jianzhang; Zhou, Fuke; Guo, Huimin
European Journal of Organic Chemistry, 2011 , # 30 p. 6100 - 6109
反应条件
1: Heating 2: 1.) triethyloxonium fluoroborate / 1.) ClCH2CH2Cl, reflux 16 h View Scheme
参考文献
Meyers, A. I.; Hellring, Stuart
Tetrahedron Letters, 1981 , vol. 22, # 51 p. 5119 - 5122
反应条件
dihydrogen peroxide; iodine in water T=20°C;
参考文献
AKAAL PHARMA PTY LTD; GILL, Gurmit, S.; GROBELNY, Damian, W.
Patent: WO2010/42998 A1, 2010 ;
Location in patent: Page/Page column 56 ;
WO 2010/042998 A1
反应条件
CrMCM-41; dihydrogen peroxide in methanol Oxidation; 20 h; Heating;
参考文献
Chandrakala; Murthy; Kulkarni; Raghavan
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 1 p. 71 - 73
反应条件
potassium permanganate in acetone 0.333333 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 52, # 4 p. 1451 - 1460
反应条件
methanol; sodium hydroxide in water T=80°C; 24 h;
参考文献
Synlett, , # 8 art. no. U00511ST, p. 1121 - 1124
反应条件
1: palladium 10 on activated carbon / 24 h / 150 °C / Autoclave 2: palladium 10 on activated carbon; zinc / water; isopropyl alcohol / 40 h / 150 °C / Autoclave View Scheme
参考文献
Abarca, Belen; Adam, Rosa; Ballesteros, Rafael
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1826 - 1833
反应条件
T=275 - 280°C; im Rohr;
参考文献
Padoa; Scagliarini
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1908 , vol. <5> 17 I, p. 730
Gazzetta Chimica Italiana, 1909 , vol. 39 I, p. 379
