1,2,3,4-四氢喹啉合成路线 （共 372 条）
反应条件
1: sodium acetate; aqueous acetone 2: aluminium chloride View Scheme
参考文献
Sugimoto
Yakugaku Zasshi, 1944 , vol. 64, # 7 p. 4
Chem.Abstr., 1952 , p. 114
反应条件
in tetrahydrofuran 24 h; Ambient temperature;
参考文献
ARQULE, INC.
Patent: WO2006/86484 A1, 2006 ;
Location in patent: Page/Page column 51 ;
反应条件
1: tetrahydrofuran / 24 h / Ambient temperature 2: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C 3: 94 percent / aq. NaOH / ethanol / 2 h / Heating 4: 93 percent / copper chromite, quinoline / 3 h / 185 °C View Scheme
参考文献
Abarca, Belen; Adam, Rosa; Ballesteros, Rafael
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1826 - 1833
反应条件
sulfuric acid; bromine; silver sulphate T=0°C; Inert atmosphere;
参考文献
Kolmakov, Kirill; Belov, Vladimir N.; Wurm, Christian A.; Harke, Benjamin; Leutenegger, Marcel; Eggeling, Christian; Hell, Stefan W.
European Journal of Organic Chemistry, 2010 , # 19 p. 3593 - 3610
反应条件
1: tetrahydrofuran / 14 h / 0 - 25 °C 2: sulfuric acid; potassium nitrate / 0.5 h / 0 °C 3: methanol; potassium carbonate / water / 1 h / Reflux View Scheme
参考文献
Cordeiro, Alessandra; Shaw, Julian; O'Brien, John; Blanco, Fernando; Rozas, Isabel
European Journal of Organic Chemistry, 2011 , # 8 p. 1504 - 1513
反应条件
sulfuric acid; potassium nitrate T=0 - 25°C; 1 h;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1504 - 1513
反应条件
1: benzene / und Erhitzen des Reaktionsprodukts mit konz. Schwefelsaeure auf 110grad 2: selenium dioxide / 175 °C View Scheme
参考文献
Cook et al.
Proceedings of the Indiana Academy of Science, 1949 , vol. 58, p. 145
反应条件
T=153.9°C; sowie bei 164.7.Decarboxylation; Rate constant;
参考文献
Schenkel; Schenkel-Rudin
Helvetica Chimica Acta, 1948 , vol. 31, p. 924,925
反应条件
(+/-)-BINAP; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate in toluene Buchwald-Hartwig reaction; Reflux;
参考文献
Buckley, Benjamin R.; Christie, Steven D. R.; Elsegood, Mark R. J.; Gillings, Claire M.; Page, Philip C. Bulman; Pardoe, William J. M.
Synlett, 2010 , # 6 p. 939 - 943
反应条件
PdCl2(PMePh2)2; oxygen; KOC(O)Ph; benzoic acid in toluene T=100°C; 36 h; Sealed tube;
参考文献
Girard, Simon A.; Knauber, Thomas; Zhou, Feng; Simon, Marc-Olivier; Li, Chao-Jun; Hu, Xiong; Deng, Guo-Jun
Organic Letters, 2012 , vol. 14, # 21 p. 5606 - 5609,4
