1,2,3,4-四氢喹啉合成路线 （共 372 条）
反应条件
dimethyl-disulfide; hydrogen in n-heptane T=623°C; simultaneous reaction of quinoline and aniline educts; var. quinoline and quinoline or aniline educts; var. catalysts; Product distribution;
参考文献
Perot, G.; Brunet, S.; Canaff, C.; Toulhoat, H.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 11-12 p. 865 - 870
参考文献
Bamberger; Williamson
Chemische Berichte, 1894 , vol. 27, p. 1470
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Bamberger; Lengfeld
Chemische Berichte, 1890 , vol. 23, p. 1142
反应条件
1: tetrahydrofuran / 24 h / Ambient temperature 2: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C 3: 94 percent / aq. NaOH / ethanol / 2 h / Heating View Scheme
参考文献
Van Wijngaarden; Hamminga; Van Hes; Standaar; Tipker; Tulp; Mol; Olivier; De Jonge
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3693 - 3699
反应条件
1: 90 percent HNO3, H2SO4 / 0 °C 2: H2 / Pd/C / ethanol View Scheme
参考文献
Higuchi, Robert I.; Edwards, James P.; Caferro, Thomas R.; Ringgenberg, Josef D.; Kong, James W.; Hamann, Lawrence G.; Arienti, Kristen L.; Marschke, Keith B.; Davis, Robert L.; Farmer, Luc J.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1335 - 1340
反应条件
dimethyl-disulfide; hydrogen in n-heptane T=623°C; simultaneous reaction of quinoline and aniline educts; var. quinoline and quinoline or aniline educts; var. catalysts; Product distribution;
参考文献
Perot, G.; Brunet, S.; Canaff, C.; Toulhoat, H.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 11-12 p. 865 - 870
反应条件
triethylamine in ethyl acetate T=0 - 20°C;
参考文献
Ueda, Satoshi; Okada, Takahiro; Nagasawa, Hideko
Chemical Communications, 2010 , vol. 46, # 14 p. 2462 - 2464
反应条件
tert.-butylhydroperoxide; sodium acetate; tetra-(n-butyl)ammonium iodide in water; acetonitrile T=90°C; 8 h;
参考文献
Zhang, Jie; Jiang, Jiewen; Li, Yuling; Zhao, Yun; Wan, Xiaobing
Organic Letters, 2013 , vol. 15, # 13 p. 3222 - 3225
反应条件
potassium iodide; potassium carbonate in acetonitrile
参考文献
Agejas-Chicharro, Javier; Belen Bueno Melendo, Ana; Camp, Nicholas Paul; Gilmore, Jeremy; Jimenez-Aguado, Alma Maria; Lamas-Peteira, Carlos; Marcos-Llorente, Alicia; Mazanetz, Michael Philip; Montero Salgado, Carlos; Timms, Graham Henry; Williams, Andrew Caerwyn
Patent: US2004/122001 A1, 2004 ;
US 20040122001 A1
反应条件
1: acetic acid 2: Raney nickel; liquid ammonia; ethanol / 120 °C / 66195.7 Torr / Hydrogenation View Scheme
参考文献
Whitmore et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 725,728
参考文献
Okimoto, Mitsuhiro; Yoshida, Takashi; Hoshi, Masayuki; Hattori, Kazuyuki; Komata, Masashi; Numata, Kaori; Tomozawa, Kenta
Australian Journal of Chemistry, 2007 , vol. 60, # 4 p. 236 - 242
