1,2,3,4-四氢喹啉合成路线 （共 372 条）
反应条件
triethylamine in dichloromethane
T=0°C; 3 h;
参考文献
LEO PHARMA A/S; GRUE-SOERENSEN, Gunnar; LIANG, Xifu; HOeGBERG, Thomas; MAaNSSON, Kristoffer; VEDSOE, Per; VIFIAN, Thomas
Patent: WO2012/83953 A1, 2012 ;
Location in patent: Page/Page column 46; 98 ;
反应条件
triethylamine in dichloromethane; toluene
T=0°C; 1 h;
参考文献
Adkison, Kim K.; Barrett, David G.; Deaton, David N.; Gampe, Robert T.; Hassell, Anne M.; Long, Stacey T.; McFadyen, Robert B.; Miller, Aaron B.; Miller, Larry R.; Payne, J. Alan; Shewchuk, Lisa M.; Wells-Knecht, Kevin J.; Willard Jr., Derril H.; Wright, Lois L.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 978 - 983
参考文献
Degussa
Patent: DE511886 , 1928 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 398
反应条件
iron tribromide; 1,2,3,4,5-pentamethylcyclopentadiene; 5-oxopyrrolidine-(R)-2-carboxylic acid in 1,2,4-trimethyl benzene
T=160°C; 24 h; Inert atmosphere;
参考文献
Zhao, Yingsheng; Foo, Siong Wan; Saito, Susumu
Angewandte Chemie - International Edition, 2011 , vol. 50, # 13 p. 3006 - 3009
反应条件
potassium acetate; acetic acid in water; N,N-dimethyl-formamide
T=20 - 40°C; Inert atmosphere;
参考文献
Kolmakov, Kirill; Belov, Vladimir N.; Wurm, Christian A.; Harke, Benjamin; Leutenegger, Marcel; Eggeling, Christian; Hell, Stefan W.
European Journal of Organic Chemistry, 2010 , # 19 p. 3593 - 3610
反应条件
sodium cyanoborohydride; benzaldehyde in methanol; acetic acid
参考文献
Pfizer Inc.
Patent: US4738972 A1, 1988 ;
反应条件
potassium carbonate in acetonitrile
T=120°C;
参考文献
Ling, Xuege; Xiong, Yan; Huang, Ruofeng; Zhang, Xiaohui; Zhang, Shuting; Chen, Changguo
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5218 - 5226
反应条件
sodium tris(acetoxy)borohydride
T=18°C; 24 h; Green chemistry; SolventReagent/catalyst;
参考文献
McGonagle, Fiona I.; MacMillan, Donna S.; Murray, Jane; Sneddon, Helen F.; Jamieson, Craig; Watson, Allan J. B.
Green Chemistry, 2013 , vol. 15, # 5 p. 1159 - 1165
反应条件
1: BCl3; AlCl3 / 1,2-dichloro-ethane
2: pyridine
View Scheme
参考文献
Pascal, Yves; Andrianjara, Charles R.; Auclair, Eric; Avenel, Nadine; Bertin, Bernadette; Calvet, Alain; Feru, Frederic; Lardon, Sophie; Moodley, Indres; Ouagued, Malika; Payne, Adrian; Pruniaux, Marie-Pierre; Szilagyi, Corinne
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 1 p. 35 - 38
参考文献
Cromwell; Witt
Journal of the American Chemical Society, 1943 , vol. 65, p. 308,310
