1,2,3,4-四氢喹啉合成路线 （共 372 条）
反应条件
trifluoromethylsulfonic anhydride
1) dichloroethane, 0 deg C; 2) dichloroethane, 2-4 h, reflux; Yield given. Multistep reaction;
参考文献
Baraznenok; Nenaidenko; Balenkova
Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 4 p. 429 - 434
参考文献
Bahner et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4198
反应条件
1: in benzene
2: With sodium hydroxide in water; benzene
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2003/87057 A1, 2003 ;
Location in patent: Page/Page column 78 ;
WO 03/087057 A1
反应条件
1: 47 percent / acetic acid / Heating
2: 80 mg / H2O; acetone / 72 h / incubation with Cunninghamella elegans
View Scheme
参考文献
Crabb, Trevor; Soilleux, Stephanie L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1381 - 1386
反应条件
T=1050°C; P=7.5006E-06 Torr; flash vacuum thermolysis;
参考文献
Pfister-Guillouzo, Genevieve; Gracian, Francoise; Senio, Anna; Letulle, Marguerite; Ripoll, Jean-Louis
Tetrahedron Letters, 1992 , vol. 33, # 39 p. 5753 - 5756
参考文献
Lutz et al.
Journal of Organic Chemistry, 1947 , vol. 12, p. 760,761, 763
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=0 - 25°C; 14 - 18 h;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2009/87649 A1, 2009 ;
Location in patent: Page/Page column 28-29 ;
WO 2009/087649 A1
反应条件
pyridine
T=20°C; 1 h;
参考文献
Uchiyama, Masanobu; Matsumoto, Yotaro; Nakamura, Shinji; Ohwada, Tomohiko; Kobayashi, Nagao; Yamashita, Natsuno; Matsumiya, Atsushi; Sakamoto, Takao
Journal of the American Chemical Society, 2004 , vol. 126, # 28 p. 8755 - 8759
参考文献
Fuhrman; Degering
Journal of the American Chemical Society, 1945 , vol. 67, p. 1245
反应条件
1: pyridine
2: ethanol; concentrated aqueous hydrochloric acid
View Scheme
参考文献
Raiziss et al.
Journal of the American Chemical Society, 1941 , vol. 63, p. 2739
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Sargent; Small
Journal of Organic Chemistry, 1946 , vol. 11, p. 175
