1.1: lithium bromide / N,N-dimethyl-formamide / 1 h / 60 °C 2.1: magnesium / tetrahydrofuran / Inert atmosphere 2.2: -70 - 20 °C / Inert atmosphere View Scheme

1.1: lithium bromide / N,N-dimethyl-formamide / 1 h / 60 °C 2.1: magnesium / diethyl ether 2.2: -70 - 20 °C View Scheme

lithium bromide in N,N-dimethyl-formamide T=60°C; 1 h;

1.1: magnesium / tetrahydrofuran 1.2: 49 h / -78 - 20 °C / Inert atmosphere 2.1: Grubb's 2nd generation catalyst / dichloromethane / Inert atmosphere; Reflux 3.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C View Scheme