3-氯苯基硼 酸片呐醇 酯合成路线 （共 15 条）
反应条件
1: tBuCH2CH2B(H)NiPr2; 3-Chlorobenzenediazonium tetrafluoroborate With bis(cyclopentadienyl)titanium dichloride in acetonitrile T=20°C; 2.5 h; 2: With methanol in acetonitrile T=0 - 20°C; 1 h; 3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile T=20°C; 4 h; Reagent/catalyst;
参考文献
UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel
Patent: WO2014/9169 A1, 2014 ;
Location in patent: Page/Page column 53-54; 67-68 ;
反应条件
in toluene T=20°C; 2 h;
参考文献
NOVO NORDISK A/S
Patent: WO2003/105860 A1, 2003 ;
Location in patent: Page 34-35 ;
WO 03/105860 A1
反应条件
n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-60°C;
参考文献
Browne, Duncan L.; Baumann, Marcus; Harji, Bashir H.; Baxendale, Ian R.; Ley, Steven V.
Organic Letters, 2011 , vol. 13, # 13 p. 3312 - 3315
反应条件
in acetone T=20°C; Inert atmosphere;
参考文献
Tsoi, Yuk-Tai; Zhou, Zhongyuan; Yu, Wing-Yiu
Organic Letters, 2011 , vol. 13, # 19 p. 5370 - 5373
反应条件
triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane Heating;
参考文献
Thompson, Alicia L. S.; Kabalka, George W.; Akula, Murthy R.; Huffman, John W.
Synthesis, 2005 , # 4 art. no. M05304SS, p. 547 - 550
反应条件
1: 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With dimethyl zinc; Mg(O-t-Bu)2 in 1,4-dioxane; hexane T=0 - 20°C; 0.5 h; Schlenk techniqueGloveboxInert atmosphere; 2: 1-bromo-3-chloro-2-iodobenzene in 1,4-dioxane; hexane T=20 - 120°C; 24 h; Schlenk techniqueGloveboxInert atmosphere; 3: With water in 1,4-dioxane; hexane T=20°C; 0.0833333 h; Schlenk techniqueGloveboxInert atmosphere; regioselective reaction;
参考文献
Nagashima, Yuki; Takita, Ryo; Yoshida, Kengo; Hirano, Keiichi; Uchiyama, Masanobu
Journal of the American Chemical Society, 2013 , vol. 135, # 50 p. 18730 - 18733
反应条件
tert.-butylnitrite; dibenzoyl peroxide in acetonitrile T=60°C; Sandmeyer reaction; 2 h;
参考文献
Mo, Fanyang; Jiang, Yubo; Qiu, Di; Zhang, Yan; Wang, Jianbo
Angewandte Chemie - International Edition, 2010 , vol. 49, # 10 p. 1846 - 1849
反应条件
1: 85 percent / pyridine / CH2Cl2 / 0.25 h / 0 °C 2: 57 percent / Et3N / PdCl2(dppf) / dioxane / Heating View Scheme
参考文献
Synthesis, , # 4 art. no. M05304SS, p. 547 - 550
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in dichloromethane; N,N-dimethyl acetamide T=80°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 5 p. 1724 - 1727
反应条件
[Ir(C8H12)(OCH3)]2; 4,4'-di-tertbutylpyridine in chlorobenzene (N2); heating mixt. of iridium compd., bipyridine deriv., benzene deriv., dodecane and silylborane deriv. at 80°C for 4 h; cooling to room temp., chromy. (silica gel, diethyl ether in hexane (gradient from 0percent to 5percent)), NMR;
参考文献
Organometallics, , vol. 27, # 22 p. 6013 - 6019
