5-乙酰基-1H-吡咯-2-羧酸合成路线 （共 4 条）
反应条件
potassium hydroxide in tetrahydrofuran
T=40 - 50°C; 2 h;
参考文献
Martyn, Derek C.; Vernall, Andrea J.; Clark, Bruce M.; Abell, Andrew D.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 12 p. 2103 - 2110
参考文献
Ciamician; Silber
Chemische Berichte, 1884 , vol. 17, p. 1150
Gazzetta Chimica Italiana, 1884 , vol. 14, p. 162
反应条件
1: 37 percent / ZnCl2 / 1,2-dichloro-ethane / 1 h / 50 °C
2: 93 percent / aq. KOH / tetrahydrofuran / 2 h / 40 - 50 °C
View Scheme
参考文献
Martyn, Derek C.; Vernall, Andrea J.; Clark, Bruce M.; Abell, Andrew D.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 12 p. 2103 - 2110
反应条件
1: AlCl3, aluminium chloride / chloroform / 1 h / Cooling with ice
2: water; potassium carbonate / 2 h / 20 °C
View Scheme
参考文献
Clark, Benjamin R.; O'Connor, Stephen; Fox, Deirdre; Leroy, Jacques; Murphy, Cormac D.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 18 p. 6306 - 6311
