5-(1-羟基乙基)-1H-吡咯-2-羧酸合成路线 （共 3 条）
反应条件
sodium hydroxide in tetrahydrofuran
T=40 - 50°C; 24 h;
参考文献
Martyn, Derek C.; Vernall, Andrea J.; Clark, Bruce M.; Abell, Andrew D.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 12 p. 2103 - 2110
反应条件
1: 95 percent / diethyl ether; tetrahydrofuran / 5 h / -23 °C
2: 17 percent / aq. NaOH / tetrahydrofuran / 24 h / 40 - 50 °C
View Scheme
参考文献
Martyn, Derek C.; Vernall, Andrea J.; Clark, Bruce M.; Abell, Andrew D.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 12 p. 2103 - 2110
反应条件
1: 61 percent / POCl3 / 1,2-dichloro-ethane / 0.25 h / Heating
2: 95 percent / diethyl ether; tetrahydrofuran / 5 h / -23 °C
3: 17 percent / aq. NaOH / tetrahydrofuran / 24 h / 40 - 50 °C
View Scheme
参考文献
Martyn, Derek C.; Vernall, Andrea J.; Clark, Bruce M.; Abell, Andrew D.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 12 p. 2103 - 2110
