(3R,4R)-叔-丁基3-羟基-4-(羟基甲基)吡咯烷-1-羧酸酯合成路线 （共 6 条）
反应条件
1: With sodium periodate in ethanol
T=0°C; 0.333333 h;
2: With sodium tetrahydroborate in ethanol
T=0°C;
参考文献
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; INDUSTRIAL RESEARCH LIMITED
Patent: WO2004/18496 A1, 2004 ;
Location in patent: Page 23-24 ;
WO 2004/018496 A1
反应条件
hydrogen; palladium on activated charcoal in methanol
24 h;
参考文献
INDUSTRIAL RESEARCH LIMITED; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
Patent: WO2007/69923 A1, 2007 ;
Location in patent: Page/Page column 18; 21 ;
反应条件
triethylamine in methanol
T=20°C; 1 h;
参考文献
INDUSTRIAL RESEARCH LIMITED
Patent: WO2005/118532 A1, 2005 ;
Location in patent: Page/Page column 23 ;
反应条件
1: 73 percent / LiAlH4 / diethyl ether; tetrahydrofuran
2: 100 percent / H2 / Pd/C / methanol / 24 h
View Scheme
参考文献
Clinch, Keith; Evans, Gary B.; Fleet, George W. J.; Furneaux, Richard H.; Johnson, Stephen W.; Lenz, Dirk H.; Mee, Simon P. H.; Rands, Peter R.; Schramm, Vern L.; Taylor Ringia, Erika A.; Tyler, Peter C.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 6 p. 1131 - 1139
反应条件
1.1: Et3N / methanol
2.1: aq. NaIO4 / ethanol / cooling
2.2: 17 g / NaBH4 / ethanol / cooling
View Scheme
参考文献
Clinch, Keith; Evans, Gary B.; Fleet, George W. J.; Furneaux, Richard H.; Johnson, Stephen W.; Lenz, Dirk H.; Mee, Simon P. H.; Rands, Peter R.; Schramm, Vern L.; Taylor Ringia, Erika A.; Tyler, Peter C.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 6 p. 1131 - 1139
反应条件
1: palladium hydroxide on carbon; hydrogen / ethanol
2: 4-(N,N-dimethlyamino)pyridine
View Scheme
参考文献
CALLAGHAN INNOVATION RESEARCH LIMITED; EVANS, Gary Brian; KELLY, Peter Michael; TYLER, Peter Charles
Patent: WO2014/73989 A1, 2014 ;
