2-二苯基甲基亚砜基乙酸合成路线 （共 16 条）
反应条件
1: With (S)-1-phenyl-ethylamine in water Heating; 2: With hydrogenchloride pH=2;
参考文献
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058
反应条件
1: 43.5 percent / 4-(dimethylamino)pyridine; 1,3-dicyclohexylcarbodiimide / CH2Cl2 2: 87 percent / lithium hydroxide / tetrahydrofuran; H2O / 0 - 20 °C View Scheme
参考文献
Osorio-Lozada, Antonio; Prisinzano, Thomas; Olivo, Horacio F.
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3811 - 3815
反应条件
1.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 1.2: 17.0 g / aq. HCl / pH 2 2.1: 65 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058
反应条件
Bacillus subtilis var. niger IFO-3180 in N,N-dimethyl-formamide T=28°C; 168 h;
参考文献
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511
反应条件
sodium hydrogencarbonate in water
参考文献
Laboratoire L. Lafon
Patent: US4927855 A1, 1990 ;
反应条件
hydrogenchloride in water 1 - 19 h; Heating / reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/103221 A2, 2007 ;
Location in patent: Page/Page column 22-23 ;
反应条件
1.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 1.2: aq. HCl / pH 2 2.1: 68 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058
反应条件
Bacillus subtilis var. niger IFO-3180 in N,N-dimethyl-formamide T=28°C; 168 h;
参考文献
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511
反应条件
in isopropyl alcohol T=20°C; Heating / reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/103221 A2, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With (S)-1-phenyl-ethylamine in water Heating; 2: With hydrogenchloride pH=2;
参考文献
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058
