2-二苯基甲基亚砜基乙酸合成路线 （共 16 条）
反应条件
1: 44.5 percent / 4-(dimethylamino)pyridine; 1,3-dicyclohexylcarbodiimide / CH2Cl2 2: 96 percent / lithium hydroxide / tetrahydrofuran; H2O / 0 - 20 °C View Scheme
参考文献
Osorio-Lozada, Antonio; Prisinzano, Thomas; Olivo, Horacio F.
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3811 - 3815
反应条件
in water T=0 - 80°C; Resolution of racemate; Purification / work up;
参考文献
WO2009/90663 A1, ;
Page/Page column 9 ;
反应条件
Bacillus subtilis var. niger IFO-3180 in N,N-dimethyl-formamide
T=28°C; 168 h;
参考文献
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511
反应条件
Bacillus subtilis var. niger IFO-3180 in N,N-dimethyl-formamide
T=28°C; 168 h;
参考文献
Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L.
Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511
反应条件
1: 43.5 percent / 4-(dimethylamino)pyridine; 1,3-dicyclohexylcarbodiimide / CH2Cl2
2: 87 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine
View Scheme
参考文献
Osorio-Lozada, Antonio; Prisinzano, Thomas; Olivo, Horacio F.
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3811 - 3815
反应条件
1: (Diphenylmethyl)sulfinylacetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: methylamine in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Jung, Jae-Chul; Lee, Yeonju; Son, Jee-Young; Lim, Eunyoung; Jung, Mankil; Oh, Seikwan
Molecules, 2012 , vol. 17, # 9 p. 10446 - 10458
