3-(氯磺酰基)苯甲酸甲酯合成路线 （共 10 条）
反应条件
in tetrahydrofuran T=20°C; 13 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; AstraZeneca AB
Patent: EP1728793 A1, 2006 ;
Location in patent: Page/Page column 127 ;
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 2: With sulfur dioxide; acetic acid; copper(l) chloride in water T=20°C; 3 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/48349 A1, 2004 ;
Location in patent: Page 67 ;
WO 2004/048349 A1
反应条件
pyridine in methanol; dichloromethane
参考文献
US6177466 B1, ;
US 6177466 B1
反应条件
phenyl sulphuryl chloride; C43H43NO3PPdS; sodium carbonate in acetone T=60°C; 12 h; Inert atmosphereSealed tube;
参考文献
Journal of the American Chemical Society, , vol. 135, # 29 p. 10638 - 10641
反应条件
1: 3-carboxybenzenesulfonyl chloride With thionyl chloride 2 h; Heating; 2: methanol 0.25 h;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 3 p. 442 - 454
参考文献
Magnetic Resonance in Chemistry, , vol. 27, # 6 p. 585 - 591
参考文献
Monatshefte fuer Chemie, , vol. 23, p. 1126,1128
反应条件
n-butyllithium 1.) THF, hexane, -70 deg C, 45 min, 2.) THF, hexane, -70 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Toja, E; Gorini, C; Zirotti, C; Barzaghi, F; Galliani, G
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 403 - 413
反应条件
1: triethylamine / dichloromethane / 20 °C 2: sodium hydroxide; water / methanol / 20 °C View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
