6-苄氧基吡啶e-3-甲醛合成路线 （共 6 条）
反应条件
1: 5-bromo-2-(phenylmethoxy)pyridine With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran 0.5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/104236 A1, 2003 ;
Location in patent: Page 169 ;
WO 03/104236 A1
反应条件
n-butyllithium in tetrahydrofuran; N-methyl-acetamide; hexane
参考文献
US2004/204397 A1, ;
US 20040204397 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / |Cooling with ice 1.2: 5 h 1.3: 0.5 h / 0 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C 2.2: 1 h / -78 °C View Scheme
参考文献
Polyhedron, , vol. 52, p. 755 - 760
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / |Cooling with ice 1.2: 5 h 1.3: 0.5 h / 0 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C 2.2: 1 h / -78 °C View Scheme
参考文献
Polyhedron, , vol. 52, p. 755 - 760
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C;
参考文献
Ueda, Mikio; Mochida, Tomoyuki; Mori, Hatsumi
Polyhedron, 2013 , vol. 52, p. 755 - 760
反应条件
N,N,N1,N1-tetramethylguanidine; ammonium chloride in chloroform
参考文献
Pfizer Inc
Patent: US2005/187266 A1, 2005 ;
