4-氯-2,5-二甲氧基苯胺合成路线 （共 12 条）
反应条件
1: With FeCl3·6H2O; carbon in methanol T=65°C; 1 h; Inert atmosphere; 2: With hydrazine hydrate in methanol T=65°C; Inert atmosphere;
参考文献
Watanabe, Kana; Iwata, Yusuke; Adachi, Satoshi; Nishikawa, Tomoyuki; Yoshida, Yuko; Kameda, Shunsuke; Ide, Mitsuaki; Saikawa, Yoko; Nakata, Masaya
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5573 - 5579
反应条件
1.1: NaNO2; AcOH; H2SO4 / 0.5 h / 40 °C 1.2: CuCl; HCl / 0.33 h / 80 °C 2.1: FeCl3*6H2O; NH2NH2; H2O / methanol / 1 h / 65 °C View Scheme
参考文献
Synlett, , # 9 p. 1474 - 1476
反应条件
1: acetic acid; aqueous nitric acid / unter Kuehlung 2: tin (II)-chloride View Scheme
参考文献
Helvetica Chimica Acta, , vol. 31, p. 525,535
反应条件
2: acetic acid; aqueous nitric acid / unter Kuehlung 3: tin (II)-chloride View Scheme
参考文献
Helvetica Chimica Acta, , vol. 31, p. 525,535
反应条件
in chloroform 4.5 h; Reflux;
参考文献
Weitman, Michal; Lerman, Keti; Nudelman, Abraham; Major, Dan Thomas; Hizi, Amnon; Herschhorn, Alon
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 447 - 467
反应条件
pyridine; phosphorus trichoride
参考文献
Fujita, Satoshi; Momiyama, Masayoshi; Kondo, Yasumitsu; Kagiyama, Naoto; Hori, Samuel H.; Toru, Takeshi
Analytical Chemistry, 1994 , vol. 66, # 8 p. 1347 - 1353
反应条件
1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: bis-[(trifluoroacetoxy)iodo]benzene / methanol; water / 2 h / 20 °C View Scheme
参考文献
Nawrat, Christopher C.; Lewis, William; Moody, Christopher J.
Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 7872 - 7881
反应条件
1: aqueous H2SO4; KI / 75 °C / Diazotization 2: copper-powder / 200 °C View Scheme
参考文献
Posternak et al.
Helvetica Chimica Acta, 1948 , vol. 31, p. 525,535
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 0.5 h;
参考文献
Nawrat, Christopher C.; Lewis, William; Moody, Christopher J.
Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 7872 - 7881
反应条件
pyridine
T=20°C; Acetylation; 24 h;
参考文献
Tomatsu, Ayumi; Takemura, Syunji; Hashimoto, Kimiko; Nakata, Masaya
Synlett, 1999 , # 9 p. 1474 - 1476
