lithium triethylborohydride in tetrahydrofuran T=20°C;

2,6-dimethylpyridine in water T=55°C; hydrolysis and methanolysis of phosphonosulfates; pH dependence; metal ion (Zn2+, Md2+) catalysis, rate constants; solvent isotope effect; Product distribution;

1: zinc(II) iodide / toluene / 15 h / 110 °C / |Inert atmosphere 2: thionyl chloride; N,N-dimethyl-formamide / 3 h / |Reflux View Scheme

2) saponification; Multistep reaction;

trimethylsilyl bromide; di-isopropyl azodicarboxylate; triphenylphosphine 1) THF, 0.5 h, 2) 1 h; Yield given. Multistep reaction;