5-(4-甲氧基苄基)-1,3,4-噻二唑-2-胺合成路线 （共 3 条）
反应条件
1: in 1,4-dioxane
T=60°C; 3 h;
2: With water in 1,4-dioxane
T=20°C;
3: With sodium hydroxide in 1,4-dioxane; water; ethyl acetate
参考文献
DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Patent: US2012/172374 A1, 2012 ;
Location in patent: Page/Page column 37 ;
反应条件
1: With trichlorophosphate
0.75 h; Reflux;
2: With water
4 h; Reflux;
3: With potassium hydroxide in water
Cooling;
参考文献
Badiger, Naveen P.; Khan, Ashraf; Kalashetti; Khazi
Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1544 - 1549
反应条件
pyridine
T=0 - 20°C;
参考文献
Wickham, Stephanie; Regan, Nicholas; West, Matthew B.; Kumar, Vidya Prasanna; Thai, Justin; Li, Pui Kai; Cook, Paul F.; Hanigan, Marie H.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 4 p. 476 - 489
