2-(1H-吡咯-1-基)噻吩-3-甲腈合成路线 （共 5 条）
反应条件
acetic acid
2 h; Heating;
参考文献
Rault, Sylvain; Lancelot, Jean-Charles; Prunier, Herve; Robba, Max; Renard, Pierre; Delagrange, Philippe; Pfeiffer, Bruno; Caignard, Daniel-Henri; Guardiola-Lemaitre, Beatrice; Hamon, Michel
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2068 - 2080
参考文献
Rault, Isabelle; Foloppe, Marie-Paule; Rault, Sylvain; Robba, Max
Heterocycles, 1993 , vol. 36, # 9 p. 2059 - 2066
反应条件
trichlorophosphate
1) 60 deg C, 20 min, 2) 100 deg C, 1 h;
参考文献
Rault, Sylvain; Effi, Yamien; Sevricourt, Michel Cugnon de; Lancelot, Jean-Charles; Robba, Max
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 17 - 21
反应条件
sodium hydroxide; water in methanol
3 h; Heating;
参考文献
Rault, Sylvain; Lancelot, Jean-Charles; Prunier, Herve; Robba, Max; Renard, Pierre; Delagrange, Philippe; Pfeiffer, Bruno; Caignard, Daniel-Henri; Guardiola-Lemaitre, Beatrice; Hamon, Michel
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2068 - 2080
反应条件
1: NaOH, H2O / methanol / 3 h / Heating
2: TEA, ClCO2Et, NaN3 / acetone; acetonitrile / 0 °C
3: 2 h / Heating
4: NaOH / H2O / 5 h / Heating
View Scheme
参考文献
Rault, Sylvain; Lancelot, Jean-Charles; Prunier, Herve; Robba, Max; Renard, Pierre; Delagrange, Philippe; Pfeiffer, Bruno; Caignard, Daniel-Henri; Guardiola-Lemaitre, Beatrice; Hamon, Michel
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2068 - 2080
