2-[(叔丁氧基)羰基氨基]-N-(苯基甲氧基)乙酰胺合成路线 （共 3 条）
反应条件
1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 2: 4-methyl-morpholine / dichloromethane / 20 °C View Scheme
参考文献
ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Cheryl, A.; JONES, Todd, K.; WANG, Dong-Hui; WEBER, Olivia; CRAVATT, Benjamin, F.; NIPHAKIS, Micah, J.; COGNETTA, Armand; CHANG, Jae Won
Patent: WO2013/142307 A1, 2013 ;
反应条件
N-ethyl-N,N-diisopropylamine; Bt-OTs in acetonitrile
T=0 - 20°C; Green chemistry;
参考文献
Palakurthy, Nani Babu; Dev, Dharm; Paikaray, Sonali; Chaudhury, Susmitnarayan; Mandal, Bhubaneswar
RSC Advances, 2014 , vol. 4, # 16 p. 7952 - 7958
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide in dichloromethane; N,N-dimethyl-formamide
T=5°C;
参考文献
Odake; Okayama; Obata; Morikawa; Hattori; Hori; Nagai
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 4 p. 1007 - 1011
