4-[2-(环丙基甲氧基)乙基]苯酚合成路线 （共 15 条）
反应条件
hydrogen; nickel in methanol P=3361.46 Torr; 5 h;
参考文献
Council of Scientific and Industrial Research
Patent: US2006/4109 A1, 2006 ;
Location in patent: Page/Page column 3-5 ;
反应条件
1: 98 percent / KO-tBu / dimethylsulfoxide / 2 h / 40 °C 2: 95 percent / diethyl zinc / hexane / 6 h / 0 °C 3: 86 percent / Raney Nickel; H2 / methanol / 5 h / 3361.46 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 23 p. 3802 - 3806
反应条件
sulfuric acid; urea; sodium nitrite in water 1 h; Heating;
参考文献
Datta, Gopal K.; Von Schenck, Henrik; Hallberg, Anders; Larhed, Mats
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3896 - 3903
反应条件
1: 86 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 2: 1.) NaH / 1.) DMF, 2.) DMF, 60 deg, 18 h 3: 84 percent / H2 / 5percent Pd/C / tetrahydrofuran / 50 - 60 °C / 2585.7 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1003 - 1011
反应条件
1: 60 percent / [(t-Bu)3PH]BF4; Cy2NMe / Herrmann's palladacycle / dimethylformamide; H2O / 1 h / 160 °C / microwave irradiation 2: 79 percent / ammonium formate / Pd on carbon / ethanol / 0.67 h / 80 °C / microwave irradiation 3: 50 percent / H2SO4; sodium nitrite; urea / H2O / 1 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 10 p. 3896 - 3903
反应条件
1: 79 percent / ammonium formate / Pd on carbon / ethanol / 0.67 h / 80 °C / microwave irradiation 2: 50 percent / H2SO4; sodium nitrite; urea / H2O / 1 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 10 p. 3896 - 3903
反应条件
1: 60 percent / [(t-Bu)3PH]BF4; Cy2NMe / Herrmann's palladacycle / dimethylformamide; H2O / 1 h / 160 °C / microwave irradiation 2: 79 percent / ammonium formate / Pd on carbon / ethanol / 0.67 h / 80 °C / microwave irradiation 3: 50 percent / H2SO4; sodium nitrite; urea / H2O / 1 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 10 p. 3896 - 3903
反应条件
1: 95 percent / diethyl zinc / hexane / 6 h / 0 °C 2: 86 percent / Raney Nickel; H2 / methanol / 5 h / 3361.46 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 23 p. 3802 - 3806
反应条件
1: 90 percent / KOH; tetrabutylammonium bromide / tetrahydrofuran / 5 h / 20 °C 2: 98 percent / KO-tBu / dimethylsulfoxide / 2 h / 40 °C 3: 95 percent / diethyl zinc / hexane / 6 h / 0 °C 4: 86 percent / Raney Nickel; H2 / methanol / 5 h / 3361.46 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 23 p. 3802 - 3806
反应条件
sodium hydroxide in ethanol 8 h; Heating;
参考文献
Datta, Gopal K.; Von Schenck, Henrik; Hallberg, Anders; Larhed, Mats
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3896 - 3903
