6-甲氧基-2-(4-甲氧苯基)苯并[b]噻吩合成路线 （共 36 条）
反应条件
1: in toluene P=760.051 Torr; 2 h; RefluxInert atmosphereDean-StarkLarge scale; 2: With methanesulfonic acid in toluene T=90°C; 4 h; Inert atmosphereLarge scale; 3: in n-heptane; toluene T=80 - 90°C; 4 h; Inert atmosphereLarge scale; Reagent/catalystSolventTemperature;
参考文献
Vicenzi, Jeffrey T.; Zhang, Tony Y.; Robey, Roger L.; Alt, Charles A.
Organic Process Research and Development, 1999 , vol. 3, # 1 p. 56 - 59
反应条件
1: NaOH / ethanol 2: polyphosphoric acid / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 8 p. 1081 - 1086
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in water T=110°C; Suzuki coupling; 12 h; Ionic liquidInert atmosphere;
参考文献
Shinde, Pravin S.; Shinde, Sandip S.; Renge, Atul S.; Patil, Gajanan H.; Rode, Ambadas B.; Pawar, Rajendra R.
Letters in Organic Chemistry, 2009 , vol. 6, # 1 p. 8 - 10
反应条件
methanesulfonic acid in chlorobenzene
反应条件
potassium hydroxide; PPA in ethanol; water; ethyl acetate
反应条件
Eosin in dimethyl sulfoxide 14 h; Irradiation;
参考文献
Hari, Durga Prasad; Hering, Thea; Koenig, Burkhard
Organic Letters, 2012 , vol. 14, # 20 p. 5334 - 5337,4
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60 - 160°C; 66 h;
参考文献
Patel, Meena V.; Rohde, Jeffrey J.; Gracias, Vijaya; Kolasa, Teodozyj
Tetrahedron Letters, 2003 , vol. 44, # 35 p. 6665 - 6667
反应条件
1: NaOH / ethanol 2: polyphosphoric acid / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 8 p. 1081 - 1086
反应条件
PPA; phosphoric acid in water; toluene
参考文献
Eli Lilly and Company
Patent: US5614639 A1, 1997 ;
