6-甲氧基-2-(4-甲氧苯基)苯并[b]噻吩合成路线 （共 36 条）
反应条件
potassium hydroxide in ethanol; water; Petroleum ether
参考文献
ELI LILLY AND COMPANY
Patent: EP819686 A1, 1998 ;
反应条件
PPA T=85 - 90°C; 1 h;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1.1: 62 percent / Br2; AcOH / 0.75 h / 20 °C 2.1: aq. KOH / 17 h / Heating 2.2: 92 percent / 1 h / 20 °C 3.1: aq. HCl; NaNO2 3.2: 57 percent / aq. HBF4 / 0 - 20 °C 4.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme
参考文献
Synthesis, , # 7 p. 970 - 974
反应条件
1.1: aq. KOH / 17 h / Heating 1.2: 92 percent / 1 h / 20 °C 2.1: aq. HCl; NaNO2 2.2: 57 percent / aq. HBF4 / 0 - 20 °C 3.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme
参考文献
Synthesis, , # 7 p. 970 - 974
反应条件
1.1: aq. HCl; NaNO2 1.2: 57 percent / aq. HBF4 / 0 - 20 °C 2.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme
参考文献
Synthesis, , # 7 p. 970 - 974
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) T=100°C; 4 h; Yield given;
参考文献
Tetrahedron Letters, , vol. 40, # 15 p. 2909 - 2912
反应条件
1: PCl5 / benzene 2: NaNH2; NH3 3: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme
参考文献
Synthesis, , # 7 p. 970 - 974
反应条件
1: NaNH2; NH3 2: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme
参考文献
Synthesis, , # 7 p. 970 - 974
反应条件
1.1: BuLi 1.2: B(OiPr)3 1.3: HCl 2.1: Na2CO3; Pd(PPh3)4 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate Suzuki coupling reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401
