6-甲氧基-2-(4-甲氧苯基)苯并[b]噻吩合成路线 （共 36 条）
反应条件
1: 74 percent / AlCl3 / CH2Cl2 2: 81 percent / BBr3 / CH2Cl2 / 3 h / 5 °C 3: 86 percent / NaH / dimethylformamide / 5 h / 50 °C View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
hydrogenchloride; thionyl chloride; ethanethiol; aluminium trichloride in tetrahydrofuran; N-methyl-acetamide; dichloromethane; water; chlorobenzene
参考文献
Eli Lilly and Company
Patent: US4656187 A1, 1987 ;
反应条件
thionyl chloride; ethanethiol; aluminium trichloride in tetrahydrofuran; N-methyl-acetamide; dichloromethane; chlorobenzene
参考文献
Luke, Wayne Douglas
Patent: US2005/137396 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
1: AlCl3 / CH2Cl2 / 1.5 h / 27 - 29 °C 2: 77.5 percent / AlCl3, EtSH / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
boron trichloride in 1,2-dichloro-ethane T=0 - 35°C; 24 h;
参考文献
Eli Lilly and Company
Patent: US6372945 B1, 2002 ;
Location in patent: Page column 16-17 ;
反应条件
pyridine hydrochloride T=220°C; 6 h;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
W-2 Raney Ni in ethanol
0.5 h; Heating;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 6-methoxy-2-(4'-methoxyphenyl)-benzo[b]thiophene With pyridine; hydrogenchloride; tributyl-amine
T=170 - 180°C;
2: With water in ethyl acetate
0.25 h;
3: acetic anhydride With triethylamine in ethyl acetate
T=25 - 65°C; 1 h;
参考文献
ERREGIERRE S.p.A.
Patent: WO2005/3116 A1, 2005 ;
Location in patent: Page 8 ;
反应条件
1: 71 percent / pyridine hydrochloride / 6 h / 220 °C
2: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 71 percent / pyridine hydrochloride / 6 h / 220 °C
2: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
