6-甲氧基-2-(4-甲氧苯基)苯并[b]噻吩合成路线 （共 36 条）
反应条件
1: 71 percent / pyridine hydrochloride / 6 h / 220 °C
2: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
aluminium trichloride in dichloromethane
T=27 - 29°C; 1.5 h; Yield given;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 74 percent / AlCl3 / CH2Cl2
2: 90 percent / NaH / dimethylformamide / 0.25 h / Ambient temperature
View Scheme
参考文献
Schmid, Christopher R.; Sluka, James P.; Duke, Kristin M.
Tetrahedron Letters, 1999 , vol. 40, # 4 p. 675 - 678
反应条件
sodium hydroxide; aluminium trichloride in water; benzene
参考文献
Eli Lilly and Company
Patent: US4133814 A1, 1979 ;
参考文献
ELI LILLY AND COMPANY
Patent: EP819686 A1, 1998 ;
反应条件
1: 71 percent / pyridine hydrochloride / 6 h / 220 °C
2: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
3: AlCl3 / 1,2-dichloro-ethane / 1 h
4: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
