6-甲氧基苯并[b]噻吩-2,3-二酮合成路线 （共 2 条）
反应条件
1: With dihydrogen peroxide; ammonium hydroxide in water
12 h;
2: With sodium hydroxide in methanol; water
12 h; Heating / reflux;
3: With hydrogenchloride in methanol; water
T=20°C; pH=< 2;
参考文献
Xie, Wenge; Herbert, Brian; Ma, Jianguo; Nguyen, Truc Minh; Schumacher, Richard; Gauss, Carla Maria; Tehim, Ashok
Patent: US2005/250808 A1, 2005 ;
Location in patent: Page/Page column 39 ;
US 20050250808 A1
反应条件
1: in diethyl ether
T=20°C; 1.5 h; Heating / reflux;
2: With AlCl3, aluminium chloride in dichloromethane
T=0 - 20°C; 0.5 h; Heating / reflux;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2005/111038 A2, 2005 ;
Location in patent: Page/Page column 61-62 ;
WO 2005/111038 A2
