2-(4-羟基苯基)苯并[b]噻吩-6-醇合成路线 （共 12 条）
反应条件
pyridine hydrochloride T=220°C; 6 h;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1.1: K2CO3 / acetone 1.2: BF3*Et2O 2.1: BuLi 2.2: B(OiPr)3 2.3: HCl 3.1: Na2CO3; Pd(PPh3)4 4.1: BBr3 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature 2: 69 percent / PPA / 1 h / 85 - 90 °C 3: 71 percent / pyridine hydrochloride / 6 h / 220 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 8 p. 1057 - 1066
反应条件
1.1: BuLi 1.2: B(OiPr)3 1.3: HCl 2.1: Na2CO3; Pd(PPh3)4 3.1: BBr3 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401
反应条件
1: Na2CO3; Pd(PPh3)4 2: BBr3 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401
反应条件
1: 69 percent / PPA / 1 h / 85 - 90 °C 2: 71 percent / pyridine hydrochloride / 6 h / 220 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature 2: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 3: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
4-(N,N-dimethlyamino)pyridine; acetic anhydride in pyridine; water
参考文献
Eli Lilly and Company
Patent: US5512684 A1, 1996 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine
Ambient temperature;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine
Ambient temperature;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
