2,2-二甲基-5-苯基二氢-3(2H)-呋喃酮合成路线 （共 20 条）
反应条件
1: oxalyl chloride
3: 58 percent / 1 weight percent rhodium acetate / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Adams, Julian; Poupart, Marc-Andre; Grenier, Louis; Schaller, Chris; Ouimet, Nathalie; Frenette, Richard
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1749 - 1752
反应条件
phosphoric acid
T=120°C;
参考文献
Nasarow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1948 , p. 107,113
Chem.Abstr., 1948 , p. 7737
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, -65 deg C, 6 h
2: 14 percent / Hg/Nafion-H, H2O / ethanol / 25 °C
View Scheme
参考文献
Saimoto, Hiroyuki; Hiyama, Tamejiro; Nozaki, Hitosi
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 10 p. 3078 - 3087
反应条件
2: 58 percent / 1 weight percent rhodium acetate / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Adams, Julian; Poupart, Marc-Andre; Grenier, Louis; Schaller, Chris; Ouimet, Nathalie; Frenette, Richard
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1749 - 1752
反应条件
zinc(II) chloride
T=100°C; 2 h;
参考文献
Inoue, Yoshio; Matsushita, Koichi; Yen, I-Fang; Imaizumi, Shin
Chemistry Letters, 1991 , # 8 p. 1377 - 1378
反应条件
1: 25 percent / NBS / CH2Cl2 / 96 h / Ambient temperature
2: 90 percent / tri-n-butyltin chloride, sodium cyanoborohydride, azobisisobutyronitrile (AIBN) / 2-methyl-propan-2-ol / 6 h / Heating
3: 1.) ozone, 2.) triphenylphosphine / 1.) methanol, methylene dichloride, -70 deg C, 2.) RT, 12 h
View Scheme
参考文献
Srikrishna
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 5 p. 479 - 480
反应条件
1: 90 percent / tri-n-butyltin chloride, sodium cyanoborohydride, azobisisobutyronitrile (AIBN) / 2-methyl-propan-2-ol / 6 h / Heating
2: 1.) ozone, 2.) triphenylphosphine / 1.) methanol, methylene dichloride, -70 deg C, 2.) RT, 12 h
View Scheme
参考文献
Srikrishna
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 5 p. 479 - 480
反应条件
ozone; triphenylphosphine
1.) methanol, methylene dichloride, -70 deg C, 2.) RT, 12 h; Yield given. Multistep reaction;
参考文献
Srikrishna
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 5 p. 479 - 480
反应条件
trifluoroacetic acid
T=35°C; equilibrium, kH/kD; Rate constant;
参考文献
Brennan, Colin M.; Hunt, Ian; Jarvis, Terence C.; Johnson, C. David; McDonnell, Peter D.
Canadian Journal of Chemistry, 1990 , vol. 68, # 10 p. 1780 - 1785
参考文献
Nasarow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1948 , p. 107,113
Chem.Abstr., 1948 , p. 7737
