1: With hydrogenchloride in water T=20 - 55°C; 2: With sodium hydroxide in tert-butyl methyl ether; water T=5 - 45°C; pH=3.2 - 12.4; Product distribution / selectivity;
参考文献
MEDIVATION NEUROLOGY, INC.
Patent: WO2009/111540 A1, 2009 ;
Location in patent: Page/Page column 26 ;