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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
S(-)-巴氯芬盐酸盐
合成路线
（共 33 条）
750649-51-5
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1: With hydrogen; nickel in methanol T=20°C; P=3800 Torr; 24 h; 2: With hydrogenchloride
参考文献
Camps, Pelayo; Munoz-Torrero, Diego; Sanchez, Laura
Tetrahedron Asymmetry, 2004 , vol. 15, # 13 p. 2039 - 2044
123632-31-5
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
hydrogenchloride T=100°C; 24.5 h;
参考文献
Armstrong, Alan; Convine, Nicola J.; Popkin, Matthew E.
Synlett, 2006 , # 10 p. 1589 - 1591
537676-64-5
→
反应条件
63701-55-3
R(+)-巴氯芬盐酸盐
+
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1: With hydrogen; Ru(II)-(S)-(-)-BINAP in methanol T=50°C; P=10343 Torr; 20 h; 2: With sodium tetrahydroborate; cobalt(II) chloride in methanol 0.5 h; 3: With hydrogenchloride T=100°C; 10 h; Title compound not separated from byproducts;
参考文献
Thakur, Vinay V.; Nikalje, Milind D.; Sudalai
Tetrahedron Asymmetry, 2003 , vol. 14, # 5 p. 581 - 586
70200-14-5
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1.1: 5.81 g / p-toluenesulfonic acid / toluene / Heating 2.1: K3Fe(CN)6; MeSO2NH2; K2CO3 / OsO4; (DHQ)2-PHAL / 2-methyl-propan-2-ol; H2O; toluene / 24 h / 25 °C 3.1: PBr3; pyridine / diethyl ether / 51 h / -20 - 0 °C 3.2: dimethylformamide / 14 h / 70 °C 3.3: NiCl2*6H2O; NaBH4 / methanol / 1 h / 25 °C 4.1: aq. HCl / 16 h / 100 °C View Scheme
参考文献
Thakur; Paraskar; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 2 p. 326 - 330
1615-02-7
4-氯肉桂酸
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1.1: 91 percent / SOCl2 2.1: 72 percent / K2CO3; BnEt3NCl / toluene / 24 h / 20 °C 3.1: 85 percent / AcOH; aq. HCl / 1 h / Heating 4.1: 21 percent / DCC; DMAP / CH2Cl2 / 20 °C 5.1: 93 percent / LiOH*H2O / tetrahydrofuran; H2O / 20 °C 6.1: H2 / Raney-Ni / methanol / 24 h / 20 °C / 3800 Torr 6.2: 91 percent / aq. HCl View Scheme
参考文献
Camps, Pelayo; Munoz-Torrero, Diego; Sanchez, Laura
Tetrahedron Asymmetry, 2004 , vol. 15, # 13 p. 2039 - 2044
20754-21-6
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1.1: 72 percent / K2CO3; BnEt3NCl / toluene / 24 h / 20 °C 2.1: 85 percent / AcOH; aq. HCl / 1 h / Heating 3.1: 21 percent / DCC; DMAP / CH2Cl2 / 20 °C 4.1: 93 percent / LiOH*H2O / tetrahydrofuran; H2O / 20 °C 5.1: H2 / Raney-Ni / methanol / 24 h / 20 °C / 3800 Torr 5.2: 91 percent / aq. HCl View Scheme
参考文献
Camps, Pelayo; Munoz-Torrero, Diego; Sanchez, Laura
Tetrahedron Asymmetry, 2004 , vol. 15, # 13 p. 2039 - 2044
24393-52-0
对氯肉桂酸乙酯
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1.1: K3Fe(CN)6; MeSO2NH2; K2CO3 / OsO4; (DHQ)2-PHAL / 2-methyl-propan-2-ol; H2O; toluene / 24 h / 25 °C 2.1: PBr3; pyridine / diethyl ether / 51 h / -20 - 0 °C 2.2: dimethylformamide / 14 h / 70 °C 2.3: NiCl2*6H2O; NaBH4 / methanol / 1 h / 25 °C 3.1: aq. HCl / 16 h / 100 °C View Scheme
参考文献
Thakur; Paraskar; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 2 p. 326 - 330
104-88-1
4-氯苯甲醛
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1.1: zinc / benzene / 6 h / Heating 2.1: 5.81 g / p-toluenesulfonic acid / toluene / Heating 3.1: K3Fe(CN)6; MeSO2NH2; K2CO3 / OsO4; (DHQ)2-PHAL / 2-methyl-propan-2-ol; H2O; toluene / 24 h / 25 °C 4.1: PBr3; pyridine / diethyl ether / 51 h / -20 - 0 °C 4.2: dimethylformamide / 14 h / 70 °C 4.3: NiCl2*6H2O; NaBH4 / methanol / 1 h / 25 °C 5.1: aq. HCl / 16 h / 100 °C View Scheme
参考文献
Thakur; Paraskar; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 2 p. 326 - 330
1006386-90-8
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1.1: PBr3; pyridine / diethyl ether / 51 h / -20 - 0 °C 1.2: dimethylformamide / 14 h / 70 °C 1.3: NiCl2*6H2O; NaBH4 / methanol / 1 h / 25 °C 2.1: aq. HCl / 16 h / 100 °C View Scheme
参考文献
Thakur; Paraskar; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 2 p. 326 - 330
159112-23-9
→
反应条件
63701-56-4
S(-)-巴氯芬盐酸盐
反应条件
1.1: 21 percent / DCC; DMAP / CH2Cl2 / 20 °C 2.1: 93 percent / LiOH*H2O / tetrahydrofuran; H2O / 20 °C 3.1: H2 / Raney-Ni / methanol / 24 h / 20 °C / 3800 Torr 3.2: 91 percent / aq. HCl View Scheme
参考文献
Camps, Pelayo; Munoz-Torrero, Diego; Sanchez, Laura
Tetrahedron Asymmetry, 2004 , vol. 15, # 13 p. 2039 - 2044
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